{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:28Z","timestamp":1787015548274,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005683","name":"Kyoto University","doi-asserted-by":"publisher","award":["125th Anniversary Commemorative Fund (Kusunoki\u2010125)"],"award-info":[{"award-number":["125th Anniversary Commemorative Fund (Kusunoki\u2010125)"]}],"id":[{"id":"10.13039\/501100005683","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Combination anesthesia such as medetomidine\u2010midazolam\u2010ketamine (MMK) is used in macaques for various research and clinical procedures. However, medetomidine can cause problematic cardiovascular side effects. Vatinoxan, a peripherally acting \u03b1\n                      <jats:sub>2<\/jats:sub>\n                      \u2010antagonist, potentially reduces these side effects and is now available with medetomidine as Zenalpha.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study evaluated a Zenalpha\u2010midazolam\u2010ketamine protocol and compared its sedative and cardiovascular effects with the MMK protocol during regular veterinary examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>While significant differences in the timeline of anesthesia were not observed between the groups, the heart rates were significantly higher, and the systolic and diastolic blood pressures and frequency of cardiac valve regurgitation were significantly lower in the ZMK group than in the MMK group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ZMK anesthesia provides benefits in terms of cardiovascular stability compared to the conventional MMK protocol in macaques without compromising the sedative effects. Its application may improve anesthesia in Japanese and rhesus macaques.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jmp.70081","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:04:41Z","timestamp":1778745881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sedative and Cardiovascular Effects of Vatinoxan During Medetomidine\u2010Midazolam\u2010Ketamine Administration in Japanese Macaques (\n                    <i>Macaca fuscata<\/i>\n                    ) and Rhesus Macaques (\n                    <i>Macaca mulatta<\/i>\n                    )"],"prefix":"10.1111","volume":"55","author":[{"given":"Moeha","family":"Ueki","sequence":"first","affiliation":[{"name":"Center for Human Evolution Modeling Research Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihisa","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Center for Human Evolution Modeling Research Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Sawada","sequence":"additional","affiliation":[{"name":"School of Laboratory Animal Science Azabu University  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunya","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology Nihon University  Tokyo Japan"},{"name":"Tsukuba Primate Research Center National Institutes of Biomedical Innovation, Health and Nutrition  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohide","family":"Ageyama","sequence":"additional","affiliation":[{"name":"Tsukuba Primate Research Center National Institutes of Biomedical Innovation, Health and Nutrition  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6502-655X","authenticated-orcid":false,"given":"Takako","family":"Miyabe\u2010Nishiwaki","sequence":"additional","affiliation":[{"name":"Center for Human Evolution Modeling Research Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.56.951"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917\u2010016\u20100721\u20109"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467\u20102987.2001.00052.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367799780578363"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0023677216631458"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.60.481"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.62.173"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.17\u20100210"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1638\/2017\u20100043R.1"},{"issue":"11","key":"e_1_2_9_11_1","first-page":"885","article-title":"A Review of the Physiological Effects of Alpha 2\u2010Agonists Related to the Clinical Use of Medetomidine in Small Animal Practice","volume":"44","author":"Sinclair M. 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