{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T04:25:54Z","timestamp":1787199954812,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Extracellular vesicles (EVs) are membrane vesicles secreted by cells that carry several bioactive molecules, which are currently used in biomedical research as a source of exosomes and to investigate their effect in response to cancer studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      EVs isolated from the supernatant of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Macaca fascicularis<\/jats:italic>\n                      <\/jats:styled-content>\n                      Mesenchymal Stem Cells (MSCs), using the commercial ExoQUICK kit, and markers validation evaluated using quantitative reverse transcription Polymerase Chain Reaction (qRT\u2010PCR). EVs were further applied on breast cancer cells (MCF\u20107) and colorectal cancer cells (WiDr).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The application of EVs to MCF\u20107 and WiDr cells showed growth inhibition and resulted in the cells' viability decreased compared to untreated cells. The apoptosis (\n                      <jats:italic>BAX<\/jats:italic>\n                      and\n                      <jats:italic>BCL2<\/jats:italic>\n                      ) and proliferation markers (\n                      <jats:italic>PCNA<\/jats:italic>\n                      and\n                      <jats:italic>P53<\/jats:italic>\n                      ) on both cells demonstrated increasing than untreated cells, expecting that the EVs prevent the cells' growth uncontrolled.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The EVs have the potential to inhibit the growth of cancer and colon cancer in\u00a0vitro, determining their potential for developing as an anticancer agent.<\/jats:p>\n                  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