{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:49:46Z","timestamp":1792068586115,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS040237"],"award-info":[{"award-number":["R01NS040237"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS126091"],"award-info":[{"award-number":["R01NS126091"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Natural hosts of simian immunodeficiency virus (SIV), including sooty mangabeys (SMs), maintain high viremia without progressing to AIDS and AIDS\u2010associated histopathogenesis. The mechanisms underlying this protection and lack of pathogenesis remain incompletely understood, particularly in relation to monocyte\/macrophage activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Plasma soluble CD163 (sCD163), monocyte CD163 expression, and monocyte subset phenotypes were quantified in uninfected and naturally SIV\u2010infected SMs and compared with uninfected and SIV\u2010infected rhesus macaques (RMs). Flow cytometry and multivariate analyses were used to assess monocyte activation and subset distribution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      sCD163 levels and CD163 surface expression were increased in SIV\u2010infected RMs but not SMs. SIV\u2010infected SMs exhibited reduced CD14\n                      <jats:sup>+<\/jats:sup>\n                      CD16\n                      <jats:sup>+<\/jats:sup>\n                      monocyte expansion and lower expression of CD64, MAC387, CD11b, and CCR2 compared with SIV\u2010infected RMs. Machine learning identified CD14\n                      <jats:sup>+<\/jats:sup>\n                      CD16\n                      <jats:sup>+<\/jats:sup>\n                      CCR8\n                      <jats:sup>+<\/jats:sup>\n                      monocytes as the top discriminator of SIV infection in SMs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings indicate a lack of monocyte activation in SMs that correlates with non\u2010pathogenic infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jmp.70104","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:05:32Z","timestamp":1786683932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nonpathogenic\n                    <scp>SIV<\/scp>\n                    Infection in Sooty Mangabeys Is Characterized by a Lack of Activation and Expansion of Monocytes"],"prefix":"10.1111","volume":"55","author":[{"given":"Caroline","family":"Soulas","sequence":"first","affiliation":[{"name":"Biology Department Boston College  Chestnut Hill Massachusetts USA"},{"name":"Innate Pharma  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8419-7784","authenticated-orcid":false,"given":"Hai Duc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Microbiology Tulane National Biomedical Research Center, Tulane University  Covington Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5343-852X","authenticated-orcid":false,"given":"Summer","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Division of Microbiology Tulane National Biomedical Research Center, Tulane University  Covington Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7611-8780","authenticated-orcid":false,"given":"Natalie","family":"Stahr","sequence":"additional","affiliation":[{"name":"Division of Microbiology Tulane National Biomedical Research Center, Tulane University  Covington Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4224-7381","authenticated-orcid":false,"given":"Tricia H.","family":"Burdo","sequence":"additional","affiliation":[{"name":"Biology Department Boston College  Chestnut Hill Massachusetts USA"},{"name":"Department of Medicine Rutgers Institute of Translational Medicine and Science, Rutgers Biomedical Health and Sciences, Rutgers University  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis J.","family":"Novembre","sequence":"additional","affiliation":[{"name":"Divsion of Microbiology and Immunology Emory National Primate Research Center, Emory University  Atlanta Georgia USA"},{"name":"Office of Environmental Health &amp; 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