{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:50:34Z","timestamp":1792068634742,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      This study evaluated the sedative and physiological effects of intramuscular (IM) or intranasal (IN) ketamine\u2013midazolam and ketamine\u2013dexmedetomidine in capuchin monkeys (\n                      <jats:italic>Sapajus<\/jats:italic>\n                      sp.).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010four capuchin monkeys were randomly assigned into four groups (6 per group) to be administered ketamine (15\u2009mg\/kg) combined with midazolam (0.5\u2009mg\/kg) or dexmedetomidine (5\u2009\u03bcg\/kg) IM (KM\n                      <jats:sub>IM<\/jats:sub>\n                      and KD\n                      <jats:sub>IM<\/jats:sub>\n                      groups, respectively) or IN (KM\n                      <jats:sub>IN<\/jats:sub>\n                      and KD\n                      <jats:sub>IN<\/jats:sub>\n                      groups, respectively). Physiological variables, sedation scores, and anesthetic recovery times were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All protocols resulted in tachypnea and heart rate values within the range indicated for the species. Blood pressure was significantly higher in KD\n                      <jats:sub>IM<\/jats:sub>\n                      compared with KM\n                      <jats:sub>IM<\/jats:sub>\n                      . All animals in KM\n                      <jats:sub>IM<\/jats:sub>\n                      and KD\n                      <jats:sub>IM<\/jats:sub>\n                      , and three animals in KM\n                      <jats:sub>IN<\/jats:sub>\n                      and KD\n                      <jats:sub>IN<\/jats:sub>\n                      , adopted lateral recumbency. Sedation, muscle relaxation, resistance to dorsal recumbency, and mandible tone scores were higher in KM\n                      <jats:sub>IM<\/jats:sub>\n                      and KD\n                      <jats:sub>IM<\/jats:sub>\n                      compared to KD\n                      <jats:sub>IN<\/jats:sub>\n                      . Posture scores were higher in KM\n                      <jats:sub>IM<\/jats:sub>\n                      and KD\n                      <jats:sub>IM<\/jats:sub>\n                      compared to KM\n                      <jats:sub>IN<\/jats:sub>\n                      . Time to standing was longer in KM\n                      <jats:sub>IM<\/jats:sub>\n                      and KD\n                      <jats:sub>IM<\/jats:sub>\n                      than in KD\n                      <jats:sub>IN<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      All protocols promoted tachypnea and few effects on HR and blood pressure. KM\n                      <jats:sub>IM<\/jats:sub>\n                      and KD\n                      <jats:sub>IM<\/jats:sub>\n                      result in deep sedation. KM\n                      <jats:sub>IN<\/jats:sub>\n                      and KD\n                      <jats:sub>IN<\/jats:sub>\n                      result in light sedation. Anesthetic recovery was faster with KD\n                      <jats:sub>IN<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jmp.70115","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:32:23Z","timestamp":1790310743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Sedative and Physiological Effects of Intramuscular or Intranasal Ketamine\u2013Midazolam and Ketamine\u2013Dexmedetomidine in Capuchin Monkeys (\n                    <i>Sapajus<\/i>\n                    sp.)"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8283-4022","authenticated-orcid":false,"given":"Viviane Horta","family":"Gomes","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Surgery Universidade Federal Rural do Rio de Janeiro, UFRRJ  Serop\u00e9dica Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anieli Vidal","family":"Stocco","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery Universidade Federal Rural do Rio de Janeiro, UFRRJ  Serop\u00e9dica Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Vit\u00f3ria","family":"de Resende","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery Universidade Federal Rural do Rio de Janeiro, UFRRJ  Serop\u00e9dica Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-8853","authenticated-orcid":false,"given":"Ana Beathriz Nascimento","family":"Farsette","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery Universidade Federal Rural do Rio de Janeiro, UFRRJ  Serop\u00e9dica Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Nogueira","family":"da Silva","sequence":"additional","affiliation":[{"name":"Veterinary, CETAS \u2013 Ibama  Serop\u00e9dica Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9641-0674","authenticated-orcid":false,"given":"Daniel de Almeida","family":"Balthazar","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery Universidade Federal Rural do Rio de Janeiro, UFRRJ  Serop\u00e9dica Rio de Janeiro 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