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Misoprostol administration via various routes has been shown to be efficacious. Oral misoprostol in particular is effective and associated with reassuring maternal and fetal outcomes. In addition, cost has become a variable in decision making regarding best practice. More research is necessary to determine the safest medication, route, dose, and interval of administration. This article reviews cervical physiology and endogenous prostaglandin activity in relation to labor, and the pharmacologic profiles of synthetic prostaglandins currently used for induction of labor.<\/jats:p>","DOI":"10.1111\/jmwh.12022","type":"journal-article","created":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T11:43:06Z","timestamp":1366198986000},"page":"133-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The Pharmacology of Prostaglandins for Induction of Labor"],"prefix":"10.1111","volume":"58","author":[{"given":"Susan M.","family":"Yount","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Lassiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-956777"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01872.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181b48ef5"},{"key":"e_1_2_13_5_1","first-page":"1","article-title":"National Vital Statistics Reports. 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