{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:30:28Z","timestamp":1787783428913,"version":"build-2784847793"},"reference-count":65,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T00:00:00Z","timestamp":1438905600000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Midwife Womens Health"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>Existing evidence implicates the placenta as the origin of some common pregnancy complications. Moreover, some maternal conditions, such as inadequate nutrition, diabetes, and obesity, are known to adversely affect placental function, with subsequent negative impact on the fetus and newborn. The placenta may also contribute to fetal programming with health consequences into adulthood, such as cardiovascular, metabolic, and mental health disorders. There is evidence that altered placental development, specifically impaired trophoblast invasion and spiral artery remodeling in the first trimester, is the origin of preeclampsia. Prenatal care providers who understand the relationships between placental health and maternal\u2010newborn health can better inform and guide women to optimize health early in pregnancy and prior to conception. This article reviews the current understanding of placental function; placental contributions to normal fetal brain development and timing of birth; and impact of maternal nutrition, obesity, and diabetes on the placenta.<\/jats:p>","DOI":"10.1111\/jmwh.12344","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T22:00:03Z","timestamp":1438984803000},"page":"360-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Fascinating and Complex Role of the Placenta in Pregnancy and Fetal Well\u2010being"],"prefix":"10.1111","volume":"60","author":[{"given":"Gwen","family":"Latendresse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Founds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/03670244.2010.524106"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/07399332.2013.798325"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/03670244.2012.719356"},{"key":"e_1_2_9_5_1","volume-title":"Obstetrics: Normal and Problem Pregnancies","author":"Gabbe S","year":"2012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781444393927"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5332.1669"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","DOI":"10.4199\/C00016ED1V01Y201008ISP009","volume-title":"Vascular Biology of the Placenta","author":"Wang Y","year":"2010"},{"key":"e_1_2_9_9_1","unstructured":"Human Physiology Wikispace.http:\/\/humanphysiology2011.wikispaces.com\/15.+Reproductive+Physiology. Accessed September 18 2014."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2003.10.004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.07.004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316301"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.172403"},{"issue":"10","key":"e_1_2_9_14_1","first-page":"772","article-title":"Active and passive transport of drugs in the human placenta","volume":"80","author":"Wloch S","year":"2009","journal-title":"Ginekol Pol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2012.141"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.082831jh"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.01.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200443080-00001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.04.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-012-0227-2"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2012.651933"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.194"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09972"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.10.005"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD08224"},{"key":"e_1_2_9_26_1","volume-title":"The Placenta and Human Developmental Programming","author":"Burton GJ","year":"2011"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920111795470868"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01663.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2006.00543.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.05.005"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2011.01.001"},{"key":"e_1_2_9_32_1","first-page":"5","volume-title":"The Placenta and Human Developmental Programming","author":"Barker DJP","year":"2011"},{"key":"e_1_2_9_33_1","volume-title":"The Placenta and Human Developmental Programming","author":"Jackson AA","year":"2011"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.08.012"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.12.016"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0515"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2009-2352"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.12.015"},{"key":"e_1_2_9_39_1","volume-title":"Pathophysiology: The Biologic Basis of Disease in Adults and Children","author":"McCance K","year":"2014"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2009.01098.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12077"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.07.009"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.2269"},{"issue":"3","key":"e_1_2_9_44_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3233\/NPM-1370313","article-title":"Pre\u2010pregnancy obesity: Maternal, neonatal and childhood outcomes","volume":"6","author":"Papachatzi E","year":"2013","journal-title":"J Neonatal Perinatal Med"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.116186"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113508815"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.05.006"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.117259"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.01.003"},{"issue":"5","key":"e_1_2_9_50_1","first-page":"1122","article-title":"Report of the American College of Obstetricians and Gynecologists\u2019 Task Force on Hypertension in Pregnancy","volume":"122","year":"2013","journal-title":"ObstetGynecol"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1986.tb07830.x"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb13182.x"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.09.015"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.04.001"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90665-0"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17987-2"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719107306232"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0595-460"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-2011.2010.00023.x"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmwh.2008.08.001"},{"key":"e_1_2_9_61_1","volume-title":"Preterm Birth: Causes, Consequences, and Prevention","author":"Behrman RE","year":"2007"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.outlook.2013.12.010"},{"key":"e_1_2_9_63_1","volume-title":"Dietary Reference Intakes for Energy, Cholesterol, Protein, and Amino Acids","year":"2005"},{"key":"e_1_2_9_64_1","first-page":"CD001055","article-title":"Psychosocial interventions for supporting women to stop smoking in pregnancy","volume":"10","author":"Chamberlain C","year":"2013","journal-title":"Cochrane Database SystRev"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1896"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.35"}],"container-title":["Journal of Midwifery &amp; Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjmwh.12344","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjmwh.12344","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jmwh.12344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T18:37:36Z","timestamp":1696271856000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jmwh.12344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/jmwh.12344"],"URL":"https:\/\/doi.org\/10.1111\/jmwh.12344","archive":["Portico"],"relation":{},"ISSN":["1526-9523","1542-2011"],"issn-type":[{"value":"1526-9523","type":"print"},{"value":"1542-2011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"2015-08-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}