{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:23:05Z","timestamp":1792646585261,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T00:00:00Z","timestamp":1478131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007162","name":"University of Nevada, Las Vegas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Midwife Womens Health"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Advocates of human maternal placentophagy report that encapsulated placenta is an excellent source of dietary iron. Our study compared the effect of ingested encapsulated placenta on maternal postpartum iron status versus that of a beef placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, double\u2010blind, placebo\u2010controlled pilot study (N = 23) was conducted among healthy human research participants experiencing a normal pregnancy. Maternal iron status was measured via hemoglobin, transferrin, and ferritin taken from blood samples drawn in the participants\u2019 homes at 4 time points: the 36th week of pregnancy, within 96 hours of parturition, between days 5 and 7 postpartum, and during week 3 postpartum. Iron concentrations in the encapsulated placenta and encapsulated beef placebo were compared using inductively coupled plasma mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010eight percent (18\/23) of study participants\u2019 hemoglobin concentrations were above the World Health Organization cutoff for gestational iron deficiency (\u2265 11.0 g\/dL) during the 36th week of pregnancy. Results revealed no statistically significant differences (hemoglobin, <jats:italic>P<\/jats:italic> = .603; ferritin, <jats:italic>P<\/jats:italic> = .852; transferrin, <jats:italic>P<\/jats:italic> = .936) in maternal iron status (including postpartum iron rebound in the first week postpartum) between women in the placenta supplement (n = 10) and placebo (n = 13) groups. Average iron concentrations were considerably higher in encapsulated placenta (0.664 mg\/g) compared to the encapsulated beef placebo (0.093 mg\/g) but provided only 24% of the recommended daily allowance (RDA) for iron among lactating women based on the study's maximum daily intake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The current study suggests that encapsulated placenta supplementation neither significantly improves nor impairs postpartum maternal iron status for women consuming the RDA of dietary iron during pregnancy and lactation, compared to a beef placebo. This may be an especially important finding for women who are iron deficient postpartum and whose only source of supplemental dietary iron is encapsulated placenta, as this may provide an inadequate source of supplemental iron in cases of deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmwh.12549","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T13:04:38Z","timestamp":1478178278000},"page":"68-79","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effects of Human Maternal Placentophagy on Maternal Postpartum Iron Status: A Randomized, Double\u2010Blind, Placebo\u2010Controlled Pilot Study"],"prefix":"10.1111","volume":"62","author":[{"given":"Laura K.","family":"Gryder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad L.","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Benyshek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/03670244.2012.719356"},{"key":"e_1_2_7_3_1","unstructured":"Placenta Benefits.info.Placenta for healing.http:\/\/placentabenefits.info\/medicinal.asp. 2007. Accessed May 13 2015."},{"key":"e_1_2_7_4_1","unstructured":"Placentanetwork.com.Independent Placenta Encapsulation Network (IPEN). Placentabbenefitshttps:\/\/www.placentanetwork.com\/your-placenta\/placenta-benefits\/. 2011. Accessed May 10 2015."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00525.2003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.009"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.09012.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.2.267"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.12.4139"},{"key":"e_1_2_7_10_1","volume-title":"Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc: a Report of the Panel on Micronutrients","author":"Institute of Medicine. Food and Nutrition Board","year":"2001"},{"key":"e_1_2_7_11_1","article-title":"Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity","author":"World Health Organization","year":"2015","journal-title":"Vitamin and mineral nutrition information system"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-011-1279-z"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/630519"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1757913911419152"},{"key":"e_1_2_7_15_1","first-page":"67","article-title":"The care and keeping of placentas","volume":"35","author":"Selander J.","year":"2009","journal-title":"Midwifery Today"},{"key":"e_1_2_7_16_1","unstructured":"Placenta Benefits.info (PBi) About PBi.PlacentaBenefits.info FAQs.http:\/\/placentabenefits.info\/FAQ.asp#DOSE. 2008. Accessed May 13 2015."},{"key":"e_1_2_7_17_1","volume-title":"Placenta: The Gift of Life","author":"Enning C.","year":"2007"},{"key":"e_1_2_7_18_1","first-page":"352","volume-title":"Chinese Herbal Medicine: Materia Medica","author":"Bensky D","year":"1993"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114086"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2007.05.002"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1995.tb05480.x"},{"key":"e_1_2_7_22_1","unstructured":"Stanbio Laboratory.STAT\u2010Site M Hgb.http:\/\/stanbio.com\/products\/stat-sitesupsup-msuphgbsup-hemoglobin-photometer. 2005. Accessed June 5 2015."},{"key":"e_1_2_7_23_1","unstructured":"EatonP.Biochemistry Reference Ranges. Eastbourne District General Hospital & Conquest Hospital Hastings Department of Clinical Chemistry Tests.http:\/\/www.esht.nhs.uk\/EasysiteWeb\/getresource.axd?AssetID=375157. 2015. Accessed June 5 2015."},{"key":"e_1_2_7_24_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences. 2nd ed","author":"Cohen J.","year":"1988"},{"key":"e_1_2_7_25_1","volume-title":"Statistical Methods for Meta\u2010Analysis","author":"Hedges L.V.","year":"1985"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1300\/J079v21n04_02"},{"key":"e_1_2_7_27_1","unstructured":"EllisP. D.Effect size calculators.http:\/\/www.polyu.edu.hk\/mm\/effectsizefaqs\/calculator\/calculator.html. 2009. Accessed November 15 2015."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.5.1280s"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf134"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.2.590S"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2002656"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2005.10.005"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.1990.tb00638.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmwh.12309"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogn.2015.10.008"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.02.030"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2016.04.005"}],"container-title":["Journal of Midwifery &amp; Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjmwh.12549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjmwh.12549","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jmwh.12549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jmwh.12549","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jmwh.12549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:44:00Z","timestamp":1693813440000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jmwh.12549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,3]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/jmwh.12549"],"URL":"https:\/\/doi.org\/10.1111\/jmwh.12549","archive":["Portico"],"relation":{},"ISSN":["1526-9523","1542-2011"],"issn-type":[{"value":"1526-9523","type":"print"},{"value":"1542-2011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,3]]},"assertion":[{"value":"2016-11-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}