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The North American Menopause Society and the American College of Obstetricians and Gynecologists have newer guidelines based on long\u2010term analyses of the WHI participants as well as emerging data from other clinical trials. Women with an intact uterus who are using systemic estrogen must also use a progestogen; however, there are 2 new selective estrogen receptor modulators on the market for use without a progestogen. This review discusses current recommendations and new medications as well as the risks and benefits related to hormone therapy. 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