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A number of behavioral measures were studied before and during the deprivation period, including a scorbutic period, during which weight loss was observed in the mice. Mice were then resuscitated with <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> supplements. During the scorbutic period, gulo\u2212\/\u2212 mice showed decreased voluntary locomotor activity, diminished physical strength, and increased preference for a highly palatable sucrose reward. These behaviors all returned to control levels following resuscitation. Altered trial times in subordinate mice in the tube test for social dominance in the <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\u2010deprived mice persisted following resuscitation and may signify a depressive\u2010like behavior in these mice. Biochemical analyses were undertaken following a second deprivation period. <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> deficiency was accompanied by decreased blood glucose levels, oxidative damage to lipids and proteins in the cortex, and decreases in dopamine and serotonin metabolites in both the cortex and striatum. Given the reasonably high proportions of the population that do not consume sufficient <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> in the diet, these data have important implications for physical and psychological function in the general population.<\/jats:p>","DOI":"10.1111\/jnc.12069","type":"journal-article","created":{"date-parts":[[2012,10,26]],"date-time":"2012-10-26T09:34:06Z","timestamp":1351244046000},"page":"363-375","source":"Crossref","is-referenced-by-count":50,"title":["Behavioral and monoamine changes following severe vitamin <scp>C<\/scp> deficiency"],"prefix":"10.1111","volume":"124","author":[{"given":"Margaret S.","family":"Ward","sequence":"first","affiliation":[{"name":"Department of Neuroscience Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lamb","sequence":"additional","affiliation":[{"name":"Department of English Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"May","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona E.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.02.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1096\/fj.02-1167fje","article-title":"Impaired adrenal catecholamine system function in mice with deficiency of the ascorbic acid transporter (SVCT2)","volume":"17","author":"Bornstein S. 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