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We previously identified <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>1\u2010104, a short peptide from the collapsin response mediator protein 2 (<jats:styled-content style=\"fixed-case\">CRMP<\/jats:styled-content>2), which disrupted the CaV2.2\u2013<jats:styled-content style=\"fixed-case\">CRMP<\/jats:styled-content>2 interaction and suppressed a model of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010related neuropathy induced by anti\u2010retroviral therapy but not traumatic neuropathy. Here, we report <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>2\u2010104 \u2013a peptide wherein the cell\u2010penetrating <jats:styled-content style=\"fixed-case\">TAT<\/jats:styled-content> motif has been supplanted with a homopolyarginine motif, which dose\u2010dependently inhibits the CaV2.2\u2013<jats:styled-content style=\"fixed-case\">CRMP<\/jats:styled-content>2 interaction and inhibits depolarization\u2010evoked Ca<jats:sup>2+<\/jats:sup> influx in sensory neurons. Ca<jats:sup>2+<\/jats:sup> influx via activation of vanilloid receptors is not affected by either peptide. Systemic administration of <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>2\u2010104 does not affect thermal or tactile nociceptive behavioral changes. Importantly, <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>2\u2010104 transiently reduces persistent mechanical hypersensitivity induced by systemic administration of the anti\u2010retroviral drug 2\u2032,3\u2032\u2010dideoxycytidine (ddC) and following tibial nerve injury (<jats:styled-content style=\"fixed-case\">TNI<\/jats:styled-content>). Possible mechanistic explanations for the broader efficacy of <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>2\u2010104 are discussed.<\/jats:p>","DOI":"10.1111\/jnc.12070","type":"journal-article","created":{"date-parts":[[2012,10,26]],"date-time":"2012-10-26T09:34:09Z","timestamp":1351244049000},"page":"869-879","source":"Crossref","is-referenced-by-count":31,"title":["Suppression of pain\u2010related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine\u2010conjugated <scp>CRMP<\/scp>2 peptide"],"prefix":"10.1111","volume":"124","author":[{"given":"Weina","family":"Ju","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Paul and Carole Stark Neurosciences Research Institute Indianapolis Indiana USA"},{"name":"Department of Neurology the First Hospital of Jilin University, Jilin University Changchun Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Norman Bethune College of Medicine, Jilin University Changchun Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohance M.","family":"Allette","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Paul and Carole Stark Neurosciences Research Institute Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Ripsch","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Paul and Carole Stark Neurosciences Research Institute Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fletcher A.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Paul and Carole Stark Neurosciences Research Institute Indianapolis Indiana USA"},{"name":"Department of Anesthesia Paul and Carole Stark Neurosciences Research Institute Indianapolis Indiana USA"},{"name":"Department of Anatomy and Cell Biology Paul and Carole Stark Neurosciences Research Institute Indianapolis Indiana USA"},{"name":"Department of Program in Medical Neurosciences Paul and Carole Stark Neurosciences Research Institute Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Paul and Carole Stark Neurosciences Research Institute Indianapolis Indiana USA"},{"name":"Department of Biochemistry and Molecular Biology Paul and Carole Stark Neurosciences Research Institute Indianapolis Indiana USA"},{"name":"Department of Anatomy and Cell Biology Paul and Carole Stark Neurosciences Research Institute Indianapolis Indiana USA"},{"name":"Department of Program in Medical Neurosciences Paul and Carole Stark Neurosciences Research Institute Indianapolis Indiana USA"},{"name":"Sophia Therapeutics LLC Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-3-38"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2006.12.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2009.07.001"},{"key":"e_1_2_7_5_1","first-page":"756","article-title":"Cardiovascular effects of omega\u2010conopeptides in conscious rats: mechanisms of action","volume":"20","author":"Bowersox S. 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