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In previous studies in striatum\u2010isolated nerve endings (synaptosomes), we found that vinpocetine decreased dopamine (<jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>) at expense of its main metabolite 3,4\u2010dihydroxyphenylacetic acid (<jats:styled-content style=\"fixed-case\">DOPAC<\/jats:styled-content>), and that 3\u2010<jats:styled-content style=\"fixed-case\">NPA<\/jats:styled-content> increased <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>, reactive oxygen species (<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\u2010quinone products formation, and decreased <jats:styled-content style=\"fixed-case\">DOPAC<\/jats:styled-content>. Therefore, in this study, the possible effect of vinpocetine on 3\u2010<jats:styled-content style=\"fixed-case\">NPA<\/jats:styled-content>\u2010induced increase in <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ROS<\/jats:styled-content>, lipid peroxidation, and <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\u2010quinone products formation in striatum synaptosomes were investigated, and compared with the effects of the antioxidant \u03b1\u2010tocopherol. Results show that the increase in <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> induced by 3\u2010<jats:styled-content style=\"fixed-case\">NPA<\/jats:styled-content> was inhibited by both 25\u00a0\u03bcM vinpocetine and 50\u00a0\u03bcM \u03b1\u2010tocopherol. Vinpocetine, as \u03b1\u2010tocopherol, also inhibited 3\u2010<jats:styled-content style=\"fixed-case\">NPA<\/jats:styled-content>\u2010induced increase in <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> (as judged by <jats:styled-content style=\"fixed-case\">DCF<\/jats:styled-content> fluorescence), lipid peroxidation (as judged by <jats:styled-content style=\"fixed-case\">TBA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> formation), and <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\u2010quinone products formation (as judged by the nitroblue tetrazolium reduction method). As in addition to the inhibition of complex <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> exerted by 3\u2010<jats:styled-content style=\"fixed-case\">NPA<\/jats:styled-content>, 3\u2010<jats:styled-content style=\"fixed-case\">NPA<\/jats:styled-content> increases <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\u2010oxidation products that in turn can inhibit other sites of the respiratory chain, the drop in <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> produced by vinpocetine and \u03b1\u2010tocopherol may importantly contribute to their protective action from oxidative damage, particularly in <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\u2010rich structures.<\/jats:p>","DOI":"10.1111\/jnc.12082","type":"journal-article","created":{"date-parts":[[2012,11,3]],"date-time":"2012-11-03T13:36:14Z","timestamp":1351949774000},"page":"233-240","source":"Crossref","is-referenced-by-count":22,"title":["Vinpocetine and \u03b1\u2010tocopherol prevent the increase in <scp>DA<\/scp> and oxidative stress induced by 3\u2010<scp>NPA<\/scp> in striatum isolated nerve endings"],"prefix":"10.1111","volume":"124","author":[{"given":"Nieves","family":"Herrera\u2010Mundo","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda Instituto de Investigaciones Biom\u00e9dicas Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Sitges","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda Instituto de Investigaciones Biom\u00e9dicas Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199808030-00001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02576692"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209042200"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.70020794.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(94)00078-R"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06789.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.09.100"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2005.03.013"},{"key":"e_1_2_7_10_1","first-page":"299","article-title":"Protective effects of vinpocetine and structurally related drugs on the lethal consequences of hypoxia in mice","volume":"286","author":"King G. 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