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In this study, the effect of an acute or subacute <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>5074 treatment on <jats:italic>in vivo<\/jats:italic> novel object recognition test and on [<jats:sup>3<\/jats:sup>H]Acetylcholine (ACh) and <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> release in pre\u2010plaque (7\u2010month\u2010old) Tg2576 mice have been compared with those induced by the \u03b3\u2010secretase inhibitor <jats:styled-content style=\"fixed-case\">LY<\/jats:styled-content>450139 (semagacestat). Vehicle\u2010treated Tg2576 mice displayed an impairment of recognition memory compared with wild\u2010type animals. This impairment was recovered in transgenic animals acutely treated with <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>5074 (30\u00a0mg\/kg), while <jats:styled-content style=\"fixed-case\">LY<\/jats:styled-content>450139 (1, 3, 10\u00a0mg\/kg) was ineffective. In frontal cortex synaptosomes from vehicle\u2010treated Tg2576 mice, K<jats:sup>+<\/jats:sup>\u2010evoked [<jats:sup>3<\/jats:sup>H]ACh release was lower than that measured in wild\u2010type mice. This reduction was absent in transgenic animals subacutely treated with <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>5074 (30\u00a0mg\/kg daily for 8\u00a0days), while it was slightly, not significantly, amplified by <jats:styled-content style=\"fixed-case\">LY<\/jats:styled-content>450139 (3\u00a0mg\/kg daily for 8\u00a0days). There were no differences between the groups on spontaneous [<jats:sup>3<\/jats:sup>H]ACh release as well as spontaneous and K<jats:sup>+<\/jats:sup>\u2010evoked <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> release. These results suggest that <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>5074 has beneficial effects on visual memory and cortical cholinergic dysfunctions in pre\u2010plaque Tg2576 mice. Together with previous findings, these data suggest that <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>5074 could be a possible candidate for early Alzheimer's disease therapeutic regimens.<\/jats:p>","DOI":"10.1111\/jnc.12136","type":"journal-article","created":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T12:25:02Z","timestamp":1356956702000},"page":"613-620","source":"Crossref","is-referenced-by-count":17,"title":["<scp>CHF<\/scp>5074 restores visual memory ability and pre\u2010synaptic cortical acetylcholine release in pre\u2010plaque Tg2576 mice"],"prefix":"10.1111","volume":"124","author":[{"given":"Alessandro","family":"Giuliani","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Health Science University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Beggiato","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Ferrara Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito A.","family":"Baldassarro","sequence":"additional","affiliation":[{"name":"Technologies Interdepartmental Center for Industrial Research (HST\u2010ICIR) University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Mangano","sequence":"additional","affiliation":[{"name":"Technologies Interdepartmental Center for Industrial Research (HST\u2010ICIR) University of Bologna Bologna Italy"},{"name":"IRET\u2010ONLUS Foundation Ozzano Emilia Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Giardino","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Health Science University of Bologna Bologna Italy"},{"name":"Technologies Interdepartmental Center for Industrial Research (HST\u2010ICIR) University of Bologna Bologna Italy"},{"name":"IRET\u2010ONLUS Foundation Ozzano Emilia Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno P.","family":"Imbimbo","sequence":"additional","affiliation":[{"name":"Research &amp; Development Chiesi Farmaceutici Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Ferrara Ferrara Italy"},{"name":"IRET\u2010ONLUS Foundation Ozzano Emilia Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Calz\u00e0","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Health Science University of Bologna Bologna Italy"},{"name":"Technologies Interdepartmental Center for Industrial Research (HST\u2010ICIR) University of Bologna Bologna Italy"},{"name":"IRET\u2010ONLUS Foundation Ozzano Emilia Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Ferraro","sequence":"additional","affiliation":[{"name":"IRET\u2010ONLUS Foundation Ozzano Emilia Bologna Italy"},{"name":"Department of Life Sciences and Biotechnology (SVEB) University of Ferrara Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201209109"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0536-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3233\/JAD-2011-101839","article-title":"The \u03b3\u2010secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque\u2010free Tg2576 mice","volume":"24","author":"Balducci C.","year":"2011","journal-title":"J. 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