{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T08:30:55Z","timestamp":1769848255319,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T00:00:00Z","timestamp":1361923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spinal and bulbar muscular atrophy (<jats:styled-content style=\"fixed-case\">SBMA<\/jats:styled-content>) is an inherited motor neuron disease caused by the expansion of a polyglutamine (polyQ) tract within the androgen receptor (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>) gene. The pathologic features of <jats:styled-content style=\"fixed-case\">SBMA<\/jats:styled-content> are motor neuron loss in the spinal cord and brainstem, and diffuse nuclear accumulation and nuclear inclusions of mutant <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> in residual motor neurons and certain visceral organs. <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>\u2010associated coregulator 70 (<jats:styled-content style=\"fixed-case\">ARA<\/jats:styled-content>70) was the first coregulator of <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> to be identified, and it has been shown to interact with <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> and increase its protein stability. Here, we report that genistein, an isoflavone found in soy, disrupts the interaction between <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ARA<\/jats:styled-content>70 and promotes the degradation of mutant <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> in neuronal cells and transgenic mouse models of <jats:styled-content style=\"fixed-case\">SBMA<\/jats:styled-content>. We also demonstrate that dietary genistein ameliorates behavioral abnormalities, improves spinal cord and muscle pathology, and decreases the amounts of monomeric <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> and high\u2010molecular\u2010weight mutant <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> protein aggregates in <jats:styled-content style=\"fixed-case\">SBMA<\/jats:styled-content> transgenic mice. Thus, genistein treatment may be a potential therapeutic approach for alleviating the symptoms of <jats:styled-content style=\"fixed-case\">SBMA<\/jats:styled-content> by disrupting the interactions between <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ARA<\/jats:styled-content>70.<\/jats:p>","DOI":"10.1111\/jnc.12172","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T13:38:18Z","timestamp":1359553098000},"page":"122-130","source":"Crossref","is-referenced-by-count":12,"title":["Genistein, a natural product derived from soybeans, ameliorates polyglutamine\u2010mediated motor neuron disease"],"prefix":"10.1111","volume":"126","author":[{"given":"Qiang","family":"Qiang","sequence":"first","affiliation":[{"name":"Department of Neurology Nagoya University Graduate School of Medicine Nagoya 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