{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:29:25Z","timestamp":1792798165327,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,3]],"date-time":"2013-03-03T00:00:00Z","timestamp":1362268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["ICREA Academia-2010"],"award-info":[{"award-number":["ICREA Academia-2010"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003741","name":"Catalan Institution for Research and Advanced Studies","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003741","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"crossref","award":["2009 SGR 232"],"award-info":[{"award-number":["2009 SGR 232"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Cell Death Regulation group"},{"name":"Scientific and Technical Services"},{"DOI":"10.13039\/501100005774","name":"University of Barcelona","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005774","id-type":"DOI","asserted-by":"crossref"}]},{"name":"IDIBELL","id":[{"id":"https:\/\/ror.org\/0008xqs48","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>\n                    37, also known as parkin\u2010associated endothelin\u2010like receptor (Pael\u2010R), is an orphan G protein\u2010coupled receptor (\n                    <jats:styled-content style=\"fixed-case\">GPCR<\/jats:styled-content>\n                    ) that aggregates intracellularly in a juvenile form of Parkinson's disease. However, little is known about the structure or function of this receptor. Here, in order to better understand the functioning of this receptor, we focused on the\n                    <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>\n                    37 C\u2010terminal tail, in particular on a cystein\u2010enriched region. Thus, we aimed to reveal the role of these residues on receptor plasma membrane expression and function, and also whether the presence of this cysteine\u2010rich domain is linked to the previously described receptor\u2010mediated cytotoxicity. Interestingly, while the deletion of six cysteine residues within this region did not affect receptor internalization it promoted\n                    <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>\n                    37 plasma membrane expression and signaling. Furthermore, the removal of the C\u2010terminal cysteine\u2010rich domain protected against\n                    <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>\n                    37\u2010mediated apoptosis and cell death. Overall, we identified a\n                    <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>\n                    37 domain, namely the C\u2010terminal tail cysteine\u2010rich domain, which played a critical role in receptor cell surface expression, function and\n                    <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>\n                    37\u2010mediated cytotoxicity. These results might contribute to better comprehend the pathophysiology (i.e. in Parkinson's disease) of this rather unknown member of the\n                    <jats:styled-content style=\"fixed-case\">GPCR<\/jats:styled-content>\n                    family.\n                  <\/jats:p>","DOI":"10.1111\/jnc.12196","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T02:58:44Z","timestamp":1360551524000},"page":"362-372","source":"Crossref","is-referenced-by-count":32,"title":["The Parkinson's disease\u2010associated\n                    <scp>GPR<\/scp>\n                    37 receptor\u2010mediated cytotoxicity is controlled by its intracellular cysteine\u2010rich domain"],"prefix":"10.1111","volume":"125","author":[{"given":"Jorge","family":"Gand\u00eda","sequence":"first","affiliation":[{"name":"Unitat de Farmacologia Departament de Patologia i Terap\u00e8utica Experimental Facultat de Medicina IDIBELL Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Fern\u00e1ndez\u2010Due\u00f1as","sequence":"additional","affiliation":[{"name":"Unitat de Farmacologia Departament de Patologia i Terap\u00e8utica Experimental Facultat de Medicina IDIBELL Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Morat\u00f3","sequence":"additional","affiliation":[{"name":"Unitat de Farmacologia Departament de Patologia i Terap\u00e8utica Experimental Facultat de Medicina IDIBELL Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Caltabiano","sequence":"additional","affiliation":[{"name":"Laboratori de Medicina Computacional Unitat de Bioestad\u00edstica Facultat de Medicina Universitat Aut\u00f2noma de Barcelona Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Gonz\u00e1lez\u2010Mu\u00f1iz","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica M\u00e9dica CSIC Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Pardo","sequence":"additional","affiliation":[{"name":"Laboratori de Medicina Computacional Unitat de Bioestad\u00edstica Facultat de Medicina Universitat Aut\u00f2noma de Barcelona Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Stagljar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Department of Molecular Genetics Donnelly Centre University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Ciruela","sequence":"additional","affiliation":[{"name":"Unitat de Farmacologia Departament de Patologia i Terap\u00e8utica Experimental Facultat de Medicina IDIBELL Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(80)90103-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01842.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.06.013"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4644(20000901)78:3<404::AID-JCB6>3.0.CO;2-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1677\/JME-08-0114"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)01353-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00341-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0808"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac049295f"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.74.082803.133400"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(02)00337-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(97)00336-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi9013775"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.03.013"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00197-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200610151"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00108-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00407-X"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216886"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl439"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10136"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2004.10.010"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(99)00092-3"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.12.038"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200105080-00046"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4900"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5433"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1587"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20064"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04155.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2004.09.012"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02766"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00163709"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.73.011303.074134"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/77060"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi292"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400779"},{"issue":"3","key":"e_1_2_8_39_1","first-page":"III25","article-title":"Pael receptor, endoplasmic reticulum stress, and Parkinson's disease","volume":"250","author":"Takahashi R.","year":"2003","journal-title":"J. Neurol."},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00170-7"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00143-0"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6408"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.240347797"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.12196","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.12196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.12196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:06:43Z","timestamp":1698642403000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.12196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,3]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/jnc.12196"],"URL":"https:\/\/doi.org\/10.1111\/jnc.12196","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,3]]}}}