{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:09:53Z","timestamp":1789952993860,"version":"4.0.1"},"reference-count":77,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T00:00:00Z","timestamp":1378944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cerebral ischaemia rapidly depletes cellular <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>. Whilst this deprives brain tissue of a valuable energy source, the concomitant production of adenosine mitigates the damaging effects of energy failure by suppressing neuronal activity. However, the production of adenosine and other metabolites, and their loss across the blood\u2013brain barrier, deprives the brain of substrates for the purine salvage pathway, the primary means by which the brain makes <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>. Because of this, cerebral <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content> levels remain depressed after brain injury. To test whether manipulating cellular <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content> levels in brain tissue could affect functional neuronal outcomes in response to oxygen\/glucose deprivation (<jats:styled-content style=\"fixed-case\">OGD<\/jats:styled-content>), we examined the effects of creatine and <jats:sc>d<\/jats:sc>\u2010ribose and adenine (RibAde). In hippocampal slices creatine delayed <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content> breakdown, reduced adenosine release, retarded both the depression of synaptic transmission and the anoxic depolarization caused by <jats:styled-content style=\"fixed-case\">OGD<\/jats:styled-content>, and improved the recovery of transmission. In contrast, RibAde increased cellular <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>, caused increased <jats:styled-content style=\"fixed-case\">OGD<\/jats:styled-content>\u2010induced adenosine release and accelerated the depression of synaptic transmission, but did not improve functional recovery. However, RibAde improved the viability of cerebellar granule cells when administered after <jats:styled-content style=\"fixed-case\">OGD<\/jats:styled-content>. Our data indicate that RibAde may be effective in promoting recovery of brain tissue after injury, potentially via enhancement of salvage\u2010mediated <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content> production.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc12397-fig-0007-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1111\/jnc.12397","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T07:25:38Z","timestamp":1376378738000},"page":"111-124","source":"Crossref","is-referenced-by-count":24,"title":["Modulation of intracellular <scp>ATP<\/scp> determines adenosine release and functional outcome in response to metabolic stress in rat hippocampal slices and cerebellar granule cells"],"prefix":"10.1111","volume":"128","author":[{"given":"Stephanie zur","family":"Nedden","sequence":"first","affiliation":[{"name":"School of Life Sciences University of Warwick Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander S.","family":"Doney","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular and Diabetes Medicine Medical Research Institute University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno G.","family":"Frenguelli","sequence":"additional","affiliation":[{"name":"School of Life Sciences University of Warwick Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/19390211.2012.708715"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(01)00374-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2008.02.035"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00851a033"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)01131-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-001-0133-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsgi.2003.07.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323992"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64062691.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015909789152146"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00580998"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03355.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.11.5057"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00084-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01957.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04425.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02135716"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-009-0263-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-011-1132-7"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.10009"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1989.87"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1988.tb01172.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014424"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-002-1095-8"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000040942.89393.88"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1974.tb04374.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01481-9"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00294.2007"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.4.1431"},{"key":"e_1_2_7_31_1","first-page":"283.10","article-title":"Adenosine may cause an early inhibition of synaptic transmission during anoxia","volume":"8","author":"Lipton P.","year":"1982","journal-title":"Soci. 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