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In addition, the efficacy of acute <jats:sc>l<\/jats:sc>\u2010<jats:styled-content style=\"fixed-case\">DOPA<\/jats:styled-content> treatment for the reversal of altered metabolic functions was also evaluated. Cerebral atrophy and neurochemical profile were monitored <jats:italic>in vivo<\/jats:italic> using <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> and <jats:sup>1<\/jats:sup>H <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> Spectroscopy. Cerebral energetics was studied by <jats:sup>1<\/jats:sup>H\u2010[<jats:sup>13<\/jats:sup>C]\u2010<jats:styled-content style=\"fixed-case\">NMR<\/jats:styled-content> spectroscopy in conjunction with infusion of <jats:sup>13<\/jats:sup>C labeled [1,6<jats:sup>\u201013<\/jats:sup>C<jats:sub>2<\/jats:sub>]glucose or [2\u2010<jats:sup>13<\/jats:sup>C]acetate. <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content> treatment led to reduction in paw grip strength and increased level of <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> and myo\u2010inositol in striatum and olfactory bulb. <jats:sup>13<\/jats:sup>C Labeling of glutamate\u2010C4 (1.93\u00a0\u00b1\u00a00.24 vs. 1.48\u00a0\u00b1\u00a00.06\u00a0\u03bcmol\/g), <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>\u2010C2 (0.24\u00a0\u00b1\u00a00.04 vs. 0.18\u00a0\u00b1\u00a00.02\u00a0\u03bcmol\/g) and glutamaine\u2010C4 (0.26\u00a0\u00b1\u00a00.04 vs. 0.20\u00a0\u00b1\u00a00.04\u00a0\u03bcmol\/g) from [1,6\u2010<jats:sup>13<\/jats:sup>C<jats:sub>2<\/jats:sub>]glucose was found to be decreased with <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content> exposure in striatum as well as in other brain regions. However, glutamine\u2010C4 labeling from [2\u2010<jats:sup>13<\/jats:sup>C]acetate was found to be increased in the striatum of the <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content>\u2010treated mice. Acute <jats:sc>l<\/jats:sc>\u2010<jats:styled-content style=\"fixed-case\">DOPA<\/jats:styled-content> treatment failed to normalize the increased ventricular size and level of metabolites but recovered the paw grip strength and <jats:sup>13<\/jats:sup>C labeling of amino acids from [1,6\u2010<jats:sup>13<\/jats:sup>C<jats:sub>2<\/jats:sub>]glucose and [2\u2010<jats:sup>13<\/jats:sup>C]acetate in <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content>\u2010treated mice. These data indicate that brain energy metabolism is impaired in Parkinson's disease and acute <jats:sc>l<\/jats:sc>\u2010<jats:styled-content style=\"fixed-case\">DOPA<\/jats:styled-content> therapy could temporarily recover the cerebral metabolism.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc12407-fig-0008-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><jats:p>Cerebral atrophy, neurometabolite homeostasis, and neural energetics have been evaluated in an MPTP model of Parkinson's disease using MRI, <jats:italic>in vivo<\/jats:italic> <jats:sup>1<\/jats:sup>H MRS and <jats:sup>1<\/jats:sup>H\u2010[<jats:sup>13<\/jats:sup>C]\u2010NMR spectroscopy, respectively. MPTP treatment led to reduced paw grip strength and neuronal function. Acute Levodopa treatment was able to recover the diminished motor function and cerebral function. CMRGlc, Cerebral metabolic rate of glucose oxidation; MPTP, 1\u2010Methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridin.\n<\/jats:p>","DOI":"10.1111\/jnc.12407","type":"journal-article","created":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T09:26:40Z","timestamp":1376990800000},"page":"365-377","source":"Crossref","is-referenced-by-count":56,"title":["<i>In vivo <\/i><scp>NMR<\/scp> studies of regional cerebral energetics in <scp>MPTP<\/scp> model of <scp>P<\/scp>arkinson's disease: recovery of cerebral metabolism with acute levodopa treatment"],"prefix":"10.1111","volume":"127","author":[{"given":"Puneet","family":"Bagga","sequence":"first","affiliation":[{"name":"NMR Microimaging and Spectroscopy CSIR\u2010Centre for Cellular and Molecular Biology Hyderabad Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anup N.","family":"Chugani","sequence":"additional","affiliation":[{"name":"NMR Microimaging and Spectroscopy CSIR\u2010Centre for Cellular and Molecular Biology Hyderabad Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komanduri S.","family":"Varadarajan","sequence":"additional","affiliation":[{"name":"NMR Microimaging and Spectroscopy CSIR\u2010Centre for Cellular and Molecular Biology Hyderabad Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anant B.","family":"Patel","sequence":"additional","affiliation":[{"name":"NMR Microimaging and Spectroscopy CSIR\u2010Centre for Cellular and Molecular Biology Hyderabad Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.8.777"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.08.010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199407000-00004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2005.04.016"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.11.036"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(00)00170-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.3.1194"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2660133"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2011.10.016"},{"key":"e_1_2_9_11_1","first-page":"1976","volume-title":"Proc. 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