{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:24:33Z","timestamp":1788931473542,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T00:00:00Z","timestamp":1382313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["R01 DA021325"],"award-info":[{"award-number":["R01 DA021325"]}]},{"name":"NIH","award":["R01 DA030161"],"award-info":[{"award-number":["R01 DA030161"]}]},{"name":"NIH","award":["P50 DA006634"],"award-info":[{"award-number":["P50 DA006634"]}]},{"name":"NIH","award":["K99 DA031791"],"award-info":[{"award-number":["K99 DA031791"]}]},{"name":"NIH","award":["T32 DA007246"],"award-info":[{"award-number":["T32 DA007246"]}]},{"name":"NIH","award":["F31 DA031533"],"award-info":[{"award-number":["F31 DA031533"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Tolerance to the neurochemical and psychoactive effects of cocaine after repeated use is a hallmark of cocaine addiction in humans. However, comprehensive studies on tolerance to the behavioral, psychoactive, and neurochemical effects of cocaine following contingent administration in rodents are lacking. We outlined the consequences of extended access cocaine self\u2010administration as it related to tolerance to the psychomotor activating, dopamine (\n                    <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\n                    ) elevating, and\n                    <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\n                    transporter (\n                    <jats:styled-content style=\"fixed-case\">DAT<\/jats:styled-content>\n                    ) inhibiting effects of cocaine. Cocaine self\u2010administration (1.5\u00a0mg\/kg\/inj; 40 inj; 5\u00a0days), which resulted in escalation of first hour intake, caused reductions in evoked\n                    <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\n                    release and reduced maximal rates of uptake through the\n                    <jats:styled-content style=\"fixed-case\">DAT<\/jats:styled-content>\n                    as measured by slice voltammetry in the nucleus accumbens core. Furthermore, we report reductions in cocaine\u2010induced uptake inhibition and a corresponding increase in the dose of cocaine required for 50% inhibition of\n                    <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\n                    uptake (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>i<\/jats:sub>\n                    ) at the\n                    <jats:styled-content style=\"fixed-case\">DAT<\/jats:styled-content>\n                    . Cocaine tolerance at the\n                    <jats:styled-content style=\"fixed-case\">DAT<\/jats:styled-content>\n                    translated to reductions in cocaine\u2010induced\n                    <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\n                    overflow as measured by microdialysis. In addition, cocaine\u2010induced elevations in locomotor activity and stereotypy were reduced, while rearing behavior was enhanced in animals with a history of cocaine self\u2010administration. Here, we demonstrate both neurochemical and behavioral cocaine tolerance in an extended\u2010access rodent model of cocaine abuse, which allows for a better understanding of the neurochemical and psychomotor tolerance that develops to cocaine in human addicts.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc12452-fig-0005-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>\n                  <jats:p>We demonstrate tolerance to the neurochemical and behavioral effects of cocaine following extended\u2010access cocaine self\u2010administration. With respect to neurochemistry, we show reduced cocaine\u2010induced dopamine uptake inhibition, an increased dose of cocaine required for 50% inhibition of the dopamine transporter, and reduced cocaine\u2010induced dopamine overflow. In addition, we show escalation of cocaine intake and reduced cocaine\u2010induced locomotor activity following cocaine self\u2010administration.<\/jats:p>","DOI":"10.1111\/jnc.12452","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T10:38:11Z","timestamp":1381228691000},"page":"224-232","source":"Crossref","is-referenced-by-count":72,"title":["Extended access of cocaine self\u2010administration results in tolerance to the dopamine\u2010elevating and locomotor\u2010stimulating effects of cocaine"],"prefix":"10.1111","volume":"128","author":[{"given":"Erin S.","family":"Calipari","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology Wake Forest School of Medicine Winston Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Ferris","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Wake Forest School of Medicine Winston Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara R.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Wake Forest School of Medicine Winston Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5387.298"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130051121"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-2180-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn872"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01833.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.07.007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.04.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.12.1386"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2009.08.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0016-11.2011"},{"key":"e_1_2_8_12_1","article-title":"Methylphenidate and cocaine self\u2010administration produce distinct dopamine terminal alterations","author":"Calipari E. 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