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In the nervous system, dynamin\u20102 participates in synaptic vesicle recycling, post\u2010synaptic receptor internalization, neurosecretion, and neuronal process extension. Some of these functions are shared with the other two dynamin isoforms. However, the involvement of dynamin\u20102 in neurological illnesses points to a critical function of this isoform in the nervous system. In this regard, mutations in the dynamin\u20102 gene results in two congenital neuromuscular disorders. One of them, Charcot\u2010Marie\u2010Tooth disease, affects myelination and peripheral nerve conduction, whereas the other, Centronuclear Myopathy, is characterized by a progressive and generalized atrophy of skeletal muscles, yet it is also associated with abnormalities in the nervous system. Furthermore, single nucleotide polymorphisms located in the dynamin\u20102 gene have been associated with sporadic Alzheimer's disease. In the present review, we discuss the pathogenic mechanisms implicated in these neurological disorders.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc12455-fig-0004-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/jnc.12455","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T12:56:55Z","timestamp":1381237015000},"page":"210-223","source":"Crossref","is-referenced-by-count":43,"title":["Dynamin\u20102 in nervous system disorders"],"prefix":"10.1111","volume":"128","author":[{"given":"Arlek M.","family":"Gonz\u00e1lez\u2010Jamett","sequence":"first","affiliation":[{"name":"Centro 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