{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:02:28Z","timestamp":1789761748795,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T00:00:00Z","timestamp":1388966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Argentine Agency for Promotion of Science and Technology","award":["PICT2007-01080"],"award-info":[{"award-number":["PICT2007-01080"]}]},{"name":"National Research Council","award":["PIP-00774"],"award-info":[{"award-number":["PIP-00774"]}]},{"DOI":"10.13039\/501100005363","name":"University of Buenos Aires","doi-asserted-by":"crossref","award":["20020100100093"],"award-info":[{"award-number":["20020100100093"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The endocannabinoid system, composed of cannabinoid receptors, endocannabinoids, and synthesis and degradation enzymes, is present since early stages of brain development. During this period, the endocannabinoid system is involved in the regulation of neural progenitor proliferation and specification as well as the migration and differentiation of pyramidal neurons and interneurons. Marijuana consumption during pregnancy represents a serious risk in relation to the fetal brain development since \u0394<jats:sup>9<\/jats:sup>\u2010tetrahidrocannabinol, the main active compound of <jats:italic>cannabis<\/jats:italic>, can reach the fetus through placenta and hemato\u2010encephalic barrier. Cohort studies performed on children and adolescents of mothers who consumed marijuana during pregnancy reported cognitive and comportamental abnormalities. In the present study, we examined the expression of the cannabinoid receptor CB<jats:sub>1<\/jats:sub>R during corticogenesis in radially and tangentially migrating post\u2010mitotic neurons. We found that prenatal exposure to <jats:styled-content style=\"fixed-case\">WIN<\/jats:styled-content> impaired tangential and radial migration of post\u2010mitotic neurons in the dorsal pallium. In addition, we described alterations of two transcription factors associated with proliferating and newly post\u2010mitotic glutamatergic cells in the dorsal pallium, Tbr1 and Tbr2, and disruption in the number of Cajal\u2013Retzius cells. The present results contribute to the knowledge of neurobiological substrates that determine neuro\u2010comportamental changes that will persist through post\u2010natal life.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc12636-fig-0008-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><jats:p>\nDuring corticogenesis, the endocannabinoid system plays an important role in neural progenitor proliferation, specification, neuronal migration, and differentiation. Children prenatally exposed to marijuana have a significant impairment of higher cognitive functions. We showed in the present study that Prenatal WIN55,212\u20102 exposure alters radial and tangential migration and induces a delay in glutamatergic neurons differentiation in the embryonic rat cerebral cortex. The present results contribute to the knowledge on neurobiological substrates that determine neurobehavioral changes that will persist through post\u2010natal life.<\/jats:p>","DOI":"10.1111\/jnc.12636","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T16:51:09Z","timestamp":1386867069000},"page":"637-648","source":"Crossref","is-referenced-by-count":80,"title":["Prenatal exposure to the <scp>CB<\/scp><sub>1<\/sub> and <scp>CB<\/scp><sub>2<\/sub> cannabinoid receptor agonist <scp>WIN<\/scp> 55,212\u20102 alters migration of early\u2010born glutamatergic neurons and <scp>GABA<\/scp>ergic interneurons in the rat cerebral cortex"],"prefix":"10.1111","volume":"129","author":[{"given":"Trinidad M. M.","family":"Saez","sequence":"first","affiliation":[{"name":"Instituto de Biolog\u00eda Celular y Neurociencia \"Prof. E. De Robertis\" (IBCN) UBA\u2010CONICET Facultad de Medicina Universidad de Buenos Aires Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda P.","family":"Aronne","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Celular y Neurociencia \"Prof. E. De Robertis\" (IBCN) UBA\u2010CONICET Facultad de Medicina Universidad de Buenos Aires Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Caltana","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Celular y Neurociencia \"Prof. E. De Robertis\" (IBCN) UBA\u2010CONICET Facultad de Medicina Universidad de Buenos Aires Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia H.","family":"Brusco","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Celular y Neurociencia \"Prof. E. De Robertis\" (IBCN) UBA\u2010CONICET Facultad de Medicina Universidad de Buenos Aires Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00710.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.10.034"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi076"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509494102"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1137406"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02156-2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.10.013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0681-12.2012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.03.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2899-04.2005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80777-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00654"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00211-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2013.09.014"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(89)90380-9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-009-0027-z"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05565.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1033-06.2006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.025502"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.112.125468"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0537849100"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2151"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp028"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803545105"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2008.00048.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.575410"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.10.031"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2005.12.008"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00825"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.043711"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06484.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07337.x"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.12636","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.12636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.12636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:46:18Z","timestamp":1696225578000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.12636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,6]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/jnc.12636"],"URL":"https:\/\/doi.org\/10.1111\/jnc.12636","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,6]]}}}