{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:21:32Z","timestamp":1791066092173,"version":"4.1.0"},"reference-count":162,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T00:00:00Z","timestamp":1388620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AG-23524"],"award-info":[{"award-number":["AG-23524"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AG-18357"],"award-info":[{"award-number":["AG-18357"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AG-31846"],"award-info":[{"award-number":["AG-31846"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hanna-Bragard-Apfel Foundation"},{"DOI":"10.13039\/100010146","name":"Alzheimer Forschung Initiative","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010146","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High serum\/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>). Some reports, mostly retrospective epidemiological studies, have observed a decreased prevalence of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in patients taking the cholesterol lowering drugs, statins. The strongest evidence causally linking cholesterol to <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> is provided by experimental studies showing that adding\/reducing cholesterol alters amyloid precursor protein (<jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>) and amyloid beta\u2010protein (A\u03b2) levels. However, there are problems with the cholesterol\u2010<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> hypothesis. Cholesterol levels in serum\/plasma and brain of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients do not support cholesterol as a causative factor in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. Prospective studies on statins and <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> have largely failed to show efficacy. Even the experimental data are open to interpretation given that it is well\u2010established that modification of cholesterol levels has effects on multiple proteins, not only amyloid precursor protein and A\u03b2. The purpose of this review, therefore, was to examine the above\u2010mentioned issues, discuss the pros and cons of the cholesterol\u2010<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> hypothesis, involvement of other lipids in the mevalonate pathway, and consider that AD may impact cholesterol homeostasis.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc12637-fig-0005-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><jats:p>High serum\/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's disease (AD). This Review addresses the Pro's and Con's of whether cholesterol is a causative factor in AD, covering articles ranging from human to cell culture studies, both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Among others, we review models of how abeta could act on a membrane and of how abeta might be perturbing cholesterol in a cell.<\/jats:p>","DOI":"10.1111\/jnc.12637","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T16:51:09Z","timestamp":1386867069000},"page":"559-572","source":"Crossref","is-referenced-by-count":174,"title":["Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis"],"prefix":"10.1111","volume":"129","author":[{"given":"W. Gibson","family":"Wood","sequence":"first","affiliation":[{"name":"Geriatric Research, Education and Clinical Center, VAMC Department of Pharmacology University of Minnesota School of Medicine Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Pharmacology College of Pharmacy University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter E.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Biocenter Niederursel Goethe University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter P.","family":"Eckert","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Biocenter Niederursel Goethe University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.69041746.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1219988"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.211870"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3513311"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2010.03.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:8:3:319"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002156"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00224-X"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002847"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.11.007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(98)00153-9"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0694-180"},{"key":"e_1_2_10_15_1","first-page":"1","article-title":"National Institues of Health state\u2010of\u2010the\u2010science conference statement: preventing Alzheimer's disease and cognitive decline","volume":"27","author":"Daviglus M. L.","year":"2010","journal-title":"NIH Consens. State Sci. Statements"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1136(20010315)33:4<298::AID-GLIA1028>3.0.CO;2-N"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507913200"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn300203a"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R400004-JLR200"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc969"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017234"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.05.005"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920310791330668"},{"key":"e_1_2_10_24_1","first-page":"590","article-title":"Simvastatin alters membrane cholesterol distribution and beta\u2010amyloid levels in brains of APP751SL mice","volume":"68","author":"Eckert G. P.","year":"2013","journal-title":"Pharmazie"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.135"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550160069041"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06513.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199507100-00020"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00059-7"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31828124ad"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203934200"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0813349106"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2008.05.001"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200203250-00004"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2013.07.018"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828726f5"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.140218797"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31340"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300320-JLR200"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e32813aeabf"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.050004797"},{"key":"e_1_2_10_42_1","first-page":"a006312","article-title":"Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease","volume":"3","author":"Holtzman D. M.","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2010.03.014"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8285-6"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215593"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.71041626.x"},{"key":"e_1_2_10_47_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3233\/JAD-2010-1203","article-title":"Altered distribution of RhoA in Alzheimer's disease and abetaPP overexpressing mice","volume":"19","author":"Huesa G.","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66041717.x"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.69041661.x"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301150200"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.11.037"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.06.056"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.04.049"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.6.1092"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01814-9"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)60700-1"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.132"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.06.026"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-43058"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01654-4"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7300.1447"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.12.2356-a"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.02.019"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600316103"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805556105"},{"key":"e_1_2_10_66_1","first-page":"747","article-title":"Alzheimer's peptides A\u03b21\u201040 and A\u03b21\u201028 inhibit the plasma cholesterol esterification rate","volume":"38","author":"Koudinov A. R.","year":"1996","journal-title":"Biochem. Mol. Biol. Int."},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)01042-3"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513499421"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9652"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M000602200"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(01)00050-X"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj283"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.01.011"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1041-1"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2011.06.007"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.03.013"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000178989.87072.11"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.167882"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8253-1"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.45.120403.095748"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2013.06.046"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.2741\/2710"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13266"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.263"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303415200"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-43053"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708034200"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3283935"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.12.007"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1242"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(92)90116-F"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0699"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.11.005"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8337-y"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.3797"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5298-6"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.11.5891"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03323"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0741008.x"},{"key":"e_1_2_10_100_1","doi-asserted-by":"crossref","first-page":"7226","DOI":"10.1523\/JNEUROSCI.21-18-07226.2001","article-title":"A novel action of Alzheimer's amyloid \u03b2\u2010protein (A\u03b2): Oligomeric A\u03b2 promotes lipid release","volume":"18","author":"Michikawa M.","year":"2001","journal-title":"J. Neurosci."},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.07.007"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0630-12.2012"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0862-09.2009"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63163-X"},{"issue":"2","key":"e_1_2_10_105_1","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/S0021-9258(18)33185-5","article-title":"Alteration of synaptic membrane cholesterol\/phospholipid ratio using a lipid transfer protein","volume":"258","author":"North P.","year":"1983","journal-title":"J. Biol. Chem."},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1711-10.2010"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-121990"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(01)00050-4"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000070182.02537.84"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3512"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.05.007"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201202215"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03380.x"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(94)90156-2"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91705-Q"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2012.07893.x"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.12.007"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1139\/y2012-076"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)02118-4"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21605"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2005.10.007"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2002-4304"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2011.08.009"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.3.517"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00323-1"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.01.017"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020122601002"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-8622-8_10"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2007.04.029"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1159\/000231980"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.06.073"},{"key":"e_1_2_10_132_1","first-page":"4","article-title":"Membrane domains and the \u201clipid raft\u201d concept","volume":"20","author":"Sonnino S.","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb48466.x"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(90)90024-T"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1044"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.1.103"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.19.030196.000413"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.9.1053"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.04.011"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2005.01.005"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70325-2"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220484110"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.11.017"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22039"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-156661"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0047"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000149519.47454.F2"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152009788451860"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720511795256008"},{"key":"e_1_2_10_150_1","first-page":"1","article-title":"ABC transporters and the Alzheimer's disease enigma","volume":"3","author":"Wolf A.","year":"2012","journal-title":"Front. Psychiartry"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb07278.x"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00347-S"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00018-0"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(03)00025-7"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1385\/MN:31:1-3:185"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-30380-2_7"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.07017.x"},{"key":"e_1_2_10_158_1","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1096\/fj.02-0285fje","article-title":"Function of beta\u2010amyloid in cholesterol transport: a lead to neurotoxicity","volume":"16","author":"Yao Z. X.","year":"2002","journal-title":"FASEB J."},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121239"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(83)90366-8"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2003.00134.x"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1179\/1476830511Y.0000000021"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R800009200"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.12637","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.12637","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.12637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:47:37Z","timestamp":1696225657000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.12637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,2]]},"references-count":162,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/jnc.12637"],"URL":"https:\/\/doi.org\/10.1111\/jnc.12637","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,2]]}}}