{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:17:35Z","timestamp":1792279055515,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T00:00:00Z","timestamp":1398384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010803","name":"Department of Biotechnology","doi-asserted-by":"crossref","award":["BT\/HRD\/34\/18\/2008"],"award-info":[{"award-number":["BT\/HRD\/34\/18\/2008"]}],"id":[{"id":"10.13039\/501100010803","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Angelman syndrome (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>) is a neuropsychiatric disorder characterized by autism, intellectual disability and motor disturbances. The disease is primarily caused by the loss of function of maternally inherited <jats:italic><jats:styled-content style=\"fixed-case\">UBE<\/jats:styled-content>3A<\/jats:italic>. <jats:italic>Ube3a<\/jats:italic> maternal\u2010deficient mice recapitulates many essential feature of <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>. These <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> mice have been shown to be under chronic stress and exhibits anxiety\u2010like behaviour because of defective glucocorticoid receptor signalling. Here, we demonstrate that chronic stress in these mice could lead to down\u2010regulation of parvalbumin\u2010positive interneurons in the hippocampus and basolateral amygdala from early post\u2010natal days. Down\u2010regulation of parvalbumin\u2010positive interneurons number could be because of decrease in the expression of parvalbumin in these neurons. We also find that treatment with fluoxetine, a selective serotonin reuptake inhibitor, results in restoration of impaired glucocorticoid signalling, elevated serum corticosterone level, parvalbumin\u2010positive interneurons and anxiety\u2010like behaviours. Our findings suggest that impaired glucocorticod signalling in hippocampus and amygdala of <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> mice is critical for the decrease in parvalbumin interneurons number, emergence of anxiety and other behavioural deficits and highlights the importance of fluoxetine in the recovery of these abnormalities.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc12726-fig-0010-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><jats:p>This report showed that the reduction of parvalbumin (PV) in hippocampus and basolateral amygdala (BLA) along with altered glucocorticoid receptor (GR) signalling from early post\u2010natal days results in stress and anxiety in AS mice. Fluoxetine treatment rescues GR signalling and PV expression and partially restores anxiety\u2010like behaviour. These findings suggest critical evaluation of anxiety and therapeutic implication of fluoxetine in AS patients.<\/jats:p>","DOI":"10.1111\/jnc.12726","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T21:42:54Z","timestamp":1396042974000},"page":"444-454","source":"Crossref","is-referenced-by-count":51,"title":["Reversal of reduced parvalbumin neurons in hippocampus and amygdala of Angelman syndrome model mice by chronic treatment of fluoxetine"],"prefix":"10.1111","volume":"130","author":[{"given":"Swetha K.","family":"Godavarthi","sequence":"first","affiliation":[{"name":"Cellular and Molecular Neuroscience Laboratory National Brain Research Centre Manesar Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Sharma","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Neuroscience Laboratory National Brain Research Centre Manesar Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihar Ranjan","family":"Jana","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Neuroscience Laboratory National Brain Research Centre Manesar Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997-75"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00191452"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.04.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(00)00024-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010669107"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300581"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.9.1.75"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.1997.7.17"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043030"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.12.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn107"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr614"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.026"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.06.030"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.07.012"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn117"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.27.070203.144327"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.12.052"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1073\/pnas.92.11.5249-a","article-title":"A family of proteins structurally and functionally related to the E6\u2010AP ubiquitin\u2010protein ligase","volume":"92","author":"Huibregtse J. 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