{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:33:01Z","timestamp":1790764381146,"version":"4.1.0"},"reference-count":280,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T00:00:00Z","timestamp":1401235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"crossref","award":["98651"],"award-info":[{"award-number":["98651"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Huntington's disease (\n                    <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                    ) is one of many neurodegenerative diseases with reported alterations in brain iron homeostasis that may contribute to neuropathogenesis. Iron accumulation in the specific brain areas of neurodegeneration in\n                    <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                    has been proposed based on observations in post\u2010mortem tissue and magnetic resonance imaging studies. Altered magnetic resonance imaging signal within specific brain regions undergoing neurodegeneration has been consistently reported and interpreted as altered levels of brain iron. Biochemical studies using various techniques to measure iron species in human samples, mouse tissue, or\n                    <jats:italic>in vitro<\/jats:italic>\n                    has generated equivocal data to support such an association. Whether elevated brain iron occurs in\n                    <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                    , plays a significant contributing role in\n                    <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                    pathogenesis, or is a secondary effect remains currently unclear.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc12739-fig-0002-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>\n                  <jats:p>Huntington's disease (HD) is one of many neurodegenerative diseases reported to have alterations in brain iron homeostasis. Whether elevated brain iron occurs in HD, and whether elevated iron levels play a significant contributory role in HD pathogenesis remains currently unclear. In this review, we discuss potential mechanisms by which mutant huntingtin\u2010mediated increases in intracellular calcium and elevated intracellular iron may interact to result in elevated levels of reactive oxygen species leading to lipid peroxidation, DNA damage, and neuronal cell death.<\/jats:p>","DOI":"10.1111\/jnc.12739","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T09:08:34Z","timestamp":1397034514000},"page":"328-350","source":"Crossref","is-referenced-by-count":120,"title":["Iron dysregulation in Huntington's disease"],"prefix":"10.1111","volume":"130","author":[{"given":"Michelle","family":"Muller","sequence":"first","affiliation":[{"name":"Department of Medical Genetics Centre for Molecular Medicine &amp; Therapeutics University of British Columbia and Children's and Women's Hospital Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair R.","family":"Leavitt","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Centre for Molecular Medicine &amp; Therapeutics University of British Columbia and Children's and Women's Hospital Vancouver British Columbia Canada"},{"name":"Division of Neurology Department of Medicine University of British Columbia Hospital Vancouver British Columbia Canada"},{"name":"Brain Research Centre University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00297-1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(01)00063-2"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)93943-R"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005033221807"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-351957"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2008.09.004"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.12.013"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm217"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.22.2515"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2008.062133"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053606"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200001170-00004"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00477-4"},{"key":"e_1_2_12_16_1","first-page":"821","article-title":"MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer's and Huntingon's disease","volume":"46","author":"Bartzokis G.","year":"2000","journal-title":"Cell. Mol. Biol. (Noisy\u2010le\u2010grand)"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910290406"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.5.569"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1306.019"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-007-9352-7"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-06-01649.1991"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e05-07-0607"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06022"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.9.1371"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2009.01.001"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080178"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-410502-7.00011-9"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-008-9610-3"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90711-2"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1067"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)00055-B"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(96)69014-4"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00005-2"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410514"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1999.tb00216.x"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00120-3"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2721"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-01-00117.2001"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1301342110"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2006.11.001"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.07.011"},{"key":"e_1_2_12_42_1","first-page":"135","article-title":"Mitochondrial dysfunction, metabolic deficits, and increased oxidative stress in Huntington's disease","volume":"34","author":"Chen C.\u2010M.","year":"2011","journal-title":"Chang Gung Med. J."},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904519106"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077023"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1497-12.2013"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.06.035"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl319"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.08.043"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh162"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(00)00039-4"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.121"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199606)17:2<83::AID-GLIA1>3.0.CO;2-7"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10540-006-9028-6"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4619-08.2008"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92978-B"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt242"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80513-9"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr178"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42011"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00225192"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2004.02.005"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb07264.x"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.4.1953"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90346-1"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.03.044"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.8.1529"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/81593"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.149.2.357"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.056"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-387"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7618107"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl210"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.002451"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19990915)57:6<782::AID-JNR3>3.0.CO;2-9"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20684"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1993.1006"},{"key":"e_1_2_12_77_1","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1523\/JNEUROSCI.17-09-03052.1997","article-title":"Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum","volume":"17","author":"Ferrante R. J.","year":"1997","journal-title":"J. Neurosci."},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6724"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05537.x"},{"key":"e_1_2_12_80_1","first-page":"n\/a","article-title":"Multisource ascertainment of Huntington disease in Canada: prevalence and population at risk","author":"Fisher E. R.","year":"2013","journal-title":"Mov. Disord."},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000334"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.03.016"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401267200"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050109-142444"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.06.018"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.210.3.r99fe41759"},{"key":"e_1_2_12_87_1","first-page":"258","article-title":"Iron in the Parkinsonian substantia nigra","volume":"12","author":"Gerlach M.","year":"1997","journal-title":"Mov. Disord."},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033371"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2005-6-3-210"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.10.013"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.09.016"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200101)49:1<29::AID-ANA7>3.0.CO;2-B"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800048105"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2008.05.004"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000749"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-011-0181-3"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.59.3.306"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390317"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1159\/000076290"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm80"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6207"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb10990.x"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.307587"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00034"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(03)00168-3"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.1.27"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(96)00022-9"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.12.062"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(01)00296-X"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22485"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401358"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)00948-1"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02272-1"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.19.2789"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00570.x"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.7.450"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827e07be"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi990438f"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.52.37111"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199914020-00004"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20907"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301988200"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0050-4"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1173"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.32.19385"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1096485"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00126-0"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.221451398"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2009.08.002"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-005-7910-8"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(95)00202-D"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945012802002320"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01920-7"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2677"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05321.x"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-120402"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100495"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1086\/318207"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03605.x"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/35016089"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2010.99"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2613"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1993.tb17871.x"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80826-G"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100141200"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.11.018"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2003.08.006"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200007)48:1<72::AID-ANA11>3.0.CO;2-I"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm138"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00602-0"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200412071"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(96)80097-3"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198611133152006"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2528"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00444.2004"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3730-12.2013"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.536912"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7327"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0721009.x"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.3.387"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100401200"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5175-06.2007"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21227"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806269200"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410318"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.5.1104"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02943258"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00127"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199111000-00005"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000127073.66692.8f"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90542-1"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420945"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502177102"},{"key":"e_1_2_12_174_1","first-page":"677","article-title":"Reduced signal intensity of T2 weighted MR imaging of thalamus and putamen in multiple sclerosis in Japan","volume":"40","author":"Nishii T.","year":"2000","journal-title":"Rinsho Shinkeigaku"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq280"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3109"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2056"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)01312-2"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12300"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1306.001"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi300752r"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008922200"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2010.04.003"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000222734.56412.17"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.06.027"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.11.037"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.006"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R111.326876"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530310053012"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22479"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3283118434"},{"key":"e_1_2_12_192_1","first-page":"593","article-title":"Anticipation and instability of IT\u201015 (CAG)n repeats in parent\u2010offspring pairs with Huntington disease","volume":"57","author":"Ranen N. G.","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2003.03131.x"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407881102"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22303"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1362"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.10.016"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912925107"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb09150.x"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-10-03705.2000"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100044200"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.6.1025"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000065888.88988.6E"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20979"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.2945"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.03.017"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(01)00260-0"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3453"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328304b692"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.10.1713"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0445-9"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22019"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.7A7273.2007"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.05.012"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.08.001"},{"key":"e_1_2_12_216_1","first-page":"293","article-title":"Assessment of in vitro and in vivo mitochondrial function in Friedreich's ataxia and Huntington's disease","volume":"277","author":"Schapira A.","year":"2004","journal-title":"Methods Mol. Biol."},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(02)00431-8"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M513507200"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-010-9359-4"},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2838-11.2011"},{"key":"e_1_2_12_221_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1977.tb10641.x"},{"key":"e_1_2_12_222_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-101796"},{"key":"e_1_2_12_223_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022231"},{"key":"e_1_2_12_224_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20047"},{"key":"e_1_2_12_225_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1157643"},{"key":"e_1_2_12_226_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804183200"},{"key":"e_1_2_12_227_1","first-page":"743","article-title":"Iron involvement in neural damage and microgliosis in models of neurodegenerative diseases","volume":"46","author":"Shoham S.","year":"2000","journal-title":"Cell. Mol. Biol."},{"key":"e_1_2_12_228_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20526"},{"key":"e_1_2_12_229_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02815203"},{"key":"e_1_2_12_230_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01244786"},{"key":"e_1_2_12_231_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304240200"},{"key":"e_1_2_12_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.05.014"},{"key":"e_1_2_12_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.05.016"},{"key":"e_1_2_12_234_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1013"},{"key":"e_1_2_12_235_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-011-0694-6"},{"key":"e_1_2_12_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2007.05.006"},{"key":"e_1_2_12_237_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092194"},{"key":"e_1_2_12_238_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172871"},{"key":"e_1_2_12_239_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103501200"},{"key":"e_1_2_12_240_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04970.x"},{"key":"e_1_2_12_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70170-X"},{"key":"e_1_2_12_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70276-3"},{"key":"e_1_2_12_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00366-0"},{"key":"e_1_2_12_244_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409402102"},{"key":"e_1_2_12_245_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msm258"},{"key":"e_1_2_12_246_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200909067"},{"key":"e_1_2_12_247_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq047"},{"key":"e_1_2_12_248_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.19.2799"},{"key":"e_1_2_12_249_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm200605a"},{"key":"e_1_2_12_250_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22361"},{"key":"e_1_2_12_251_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0730423100"},{"key":"e_1_2_12_252_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi147"},{"key":"e_1_2_12_253_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl072"},{"key":"e_1_2_12_254_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.01.006"},{"key":"e_1_2_12_255_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207161"},{"key":"e_1_2_12_256_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1998.6832"},{"key":"e_1_2_12_257_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198511000-00003"},{"key":"e_1_2_12_258_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880050514"},{"key":"e_1_2_12_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.05.018"},{"key":"e_1_2_12_260_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22695"},{"key":"e_1_2_12_261_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20101825"},{"key":"e_1_2_12_262_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi165"},{"key":"e_1_2_12_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2008.08.006"},{"key":"e_1_2_12_264_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-18-07862.2002"},{"key":"e_1_2_12_265_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.10.004"},{"key":"e_1_2_12_266_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq174"},{"key":"e_1_2_12_267_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06445.x"},{"key":"e_1_2_12_268_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.9.1137"},{"key":"e_1_2_12_269_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg156"},{"key":"e_1_2_12_270_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1702"},{"key":"e_1_2_12_271_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870080102"},{"key":"e_1_2_12_272_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1306.025"},{"key":"e_1_2_12_273_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.12.029"},{"key":"e_1_2_12_274_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1537"},{"key":"e_1_2_12_275_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00615-3"},{"key":"e_1_2_12_276_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01980.x"},{"key":"e_1_2_12_277_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601445"},{"key":"e_1_2_12_278_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi052443r"},{"key":"e_1_2_12_279_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000838"},{"key":"e_1_2_12_280_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2007.01.003"},{"key":"e_1_2_12_281_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2009"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.12739","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.12739","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.12739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T13:43:25Z","timestamp":1696599805000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.12739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,28]]},"references-count":280,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/jnc.12739"],"URL":"https:\/\/doi.org\/10.1111\/jnc.12739","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,28]]}}}