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Recent literature has shown that genetic and drug\u2010induced elevations in dopamine transporter (\n                    <jats:styled-content style=\"fixed-case\">DAT<\/jats:styled-content>\n                    ) expression augment the neurochemical and behavioral potency of psychostimulant releasers. However, it remains to be determined if the well\u2010documented differences in\n                    <jats:styled-content style=\"fixed-case\">DAT<\/jats:styled-content>\n                    levels across striatal regions drive regionally distinct amphetamine effects within individuals.\n                    <jats:styled-content style=\"fixed-case\">DAT<\/jats:styled-content>\n                    levels and dopamine uptake rates have been shown to follow a gradient in the striatum, with the highest levels in the dorsal regions and lowest levels in the nucleus accumbens shell; thus, we hypothesized that amphetamine potency would follow this gradient. Using fast scan cyclic voltammetry in mouse brain slices, we examined\n                    <jats:styled-content style=\"fixed-case\">DAT<\/jats:styled-content>\n                    inhibition and changes in exocytotic dopamine release by amphetamine across four striatal regions (dorsal and ventral caudate\u2010putamen, nucleus accumbens core and shell). Consistent with our hypothesis, amphetamine effects at the\n                    <jats:styled-content style=\"fixed-case\">DAT<\/jats:styled-content>\n                    and on release decreased across regions from dorsal to ventral, and both measures of potency were highly correlated with dopamine uptake rates. Separate striatal subregions are involved in different aspects of motivated behaviors, such as goal\u2010directed and habitual behaviors, that become dysregulated by drug abuse, making it critically important to understand regional differences in drug potencies.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc12808-fig-0004-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>\n                  <jats:p>Amphetamine is a central nervous system psychostimulant with a high potential for abuse, which may be augmented by increased dopamine transporter (DAT) expression. We here show that the ability of amphetamine to inhibit dopamine (DA) transport and deplete dopamine vesicles increases in a graded manner across striatal subregions from ventral to dorsal with the greatest effects on DA neurotransmission in the dorsal caudate\u2010putamen. Additionally, DA uptake rate and amphetamine potency positively correlated, suggesting that differences across regions result from disparate DA transporter levels.<\/jats:p>","DOI":"10.1111\/jnc.12808","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T13:27:42Z","timestamp":1404307662000},"page":"348-355","source":"Crossref","is-referenced-by-count":39,"title":["Amphetamine potency varies with dopamine uptake rate across striatal subregions"],"prefix":"10.1111","volume":"131","author":[{"given":"Cody A.","family":"Siciliano","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin S.","family":"Calipari","sequence":"additional","affiliation":[{"name":"Fishberg Department of Neuroscience Icahn School of Medicine at Mount Sinai New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara R.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"10304","DOI":"10.1523\/JNEUROSCI.18-24-10304.1998","article-title":"Protein kinase A activity may kinetically upregulate the striatal transporter for dopamine","volume":"18","author":"Batchelor M.","year":"1998","journal-title":"J. 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