{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:09:09Z","timestamp":1779912549741,"version":"3.53.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T00:00:00Z","timestamp":1406678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009873","name":"Regione Autonoma della Sardegna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009873","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003508","name":"University of Valencia","doi-asserted-by":"crossref","award":["UV-INV_PRECOMP13-115500"],"award-info":[{"award-number":["UV-INV_PRECOMP13-115500"]}],"id":[{"id":"10.13039\/501100003508","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epidemiological studies have indicated an inverse association between high uricemia and incidence of Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>). To investigate the link between endogenous urate and neurotoxic changes involving the dopaminergic nigrostriatal system, this study evaluated the modifications in the striatal urate levels in two models of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. To this end, a partial dopaminergic degeneration was induced by 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (<jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content>) in mice, while a severe dopaminergic degeneration was elicited by unilateral medial forebrain bundle infusion of 6\u2010hydroxydopamine (6\u2010OHDA) in rats. Urate levels were measured by <jats:italic>in vivo<\/jats:italic> microdialysis at 7 or 14\u00a0days from toxin exposure. The results obtained demonstrated higher urate levels in the dopamine\u2010denervated striatum of 6\u2010OHDA\u2010lesioned rats compared with the intact striatum. Moreover, an inverse correlation between urate and dopamine levels was observed in the same area. In contrast, only a trend to significant increase in striatal urate was observed in <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content>\u2010treated mice. These results demonstrate that a damage to the dopaminergic nigrostriatal system elevates the striatal levels of urate, and suggest that this could be an endogenous compensatory mechanism to attenuate dopaminergic neurodegeneration. This finding may be important in light of the epidemiological and preclinical evidences that indicate a link between urate and development of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc12809-fig-0002-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><jats:p>This study evaluated the <jats:italic>in vivo<\/jats:italic> modifications in the striatal urate levels in the mouse MPTP and the rat 6\u2010OHDA models of Parkinson's disease\u2010like dopaminergic nigrostriatal toxicity. The results obtained demonstrated that dopaminergic neurotoxicity is associated with higher urate levels in the striatum, which would strengthen the idea of a link between endogenous urate and Parkinson's disease.<\/jats:p>","DOI":"10.1111\/jnc.12809","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T17:27:47Z","timestamp":1404322067000},"page":"284-289","source":"Crossref","is-referenced-by-count":10,"title":["Elevation of striatal urate in experimental models of Parkinson's disease: a compensatory mechanism triggered by dopaminergic nigrostriatal degeneration?"],"prefix":"10.1111","volume":"131","author":[{"given":"Maria Antonietta","family":"De Luca","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Section of Neuropsychopharmacology University of Cagliari Cagliari Italy"},{"name":"National Institute of Neuroscience (INN) University of Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Cauli","sequence":"additional","affiliation":[{"name":"Department d'Infermeria University of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaela","family":"Morelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Section of Neuropsychopharmacology University of Cagliari Cagliari Italy"},{"name":"National Institute of Neuroscience (INN) University of Cagliari Cagliari Italy"},{"name":"National Research Council (CNR) Neuroscience Institute Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Simola","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Section of Neuropsychopharmacology University of Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.11.6858"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.247"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp033"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217296110"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25646"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00568-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008954"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20663"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.7891"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-3042.2001.00676.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.03.002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2010.12.001"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12038"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06040.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3310365"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0742296.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5528"},{"key":"e_1_2_7_19_1","unstructured":"2008 Academic Press San Diego CA G. 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