{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:59:18Z","timestamp":1777103958100,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,6]],"date-time":"2014-09-06T00:00:00Z","timestamp":1409961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Korea government","award":["2011-0030072"],"award-info":[{"award-number":["2011-0030072"]}]},{"name":"Ministry of Sciencce, ICT & Future Planning","award":["2013M3A9D5072550"],"award-info":[{"award-number":["2013M3A9D5072550"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) functions as a physiological gas transmitter in both normal and pathophysiological cellular events. H<jats:sub>2<\/jats:sub>S is produced from substances by three enzymes: cystathionine \u03b2\u2010synthase (CBS), cystathionine \u03b3\u2010lyase (CSE), and 3\u2010mercaptopyruvate sulfurtransferase (MST). In human tissues, these enzymes are involved in tissue\u2010specific biochemical pathways for H<jats:sub>2<\/jats:sub>S production. For example, CBS and cysteine aminotransferase\/MST are present in the brain, but CSE is not. Thus, we examined the expression of H<jats:sub>2<\/jats:sub>S production\u2010related enzymes in peripheral nerves. Here, we found that CSE and MST\/cysteine aminotransferase, but not CBS, were present in normal peripheral nerves. In addition, injured sciatic nerves <jats:italic>in vivo<\/jats:italic> up\u2010regulated CSE in Schwann cells during Wallerian degeneration (WD); however, CSE was not up\u2010regulated in peripheral axons. Using an <jats:italic>ex vivo<\/jats:italic> sciatic nerve explant culture, we found that the inhibition of H<jats:sub>2<\/jats:sub>S production broadly prevented the process of nerve degeneration, including myelin fragmentation, axonal degradation, Schwann cell dedifferentiation, and Schwann cell proliferation <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Thus, these results indicate that H<jats:sub>2<\/jats:sub>S signaling is essential for Schwann cell responses to peripheral nerve injury.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc12932-fig-0008-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><jats:p>Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) functions as a physiological gas transmitter in both normal and pathophysiological cellular events. H<jats:sub>2<\/jats:sub>S is produced from cystathionine \u03b2\u2010synthase (CBS), cystathionine \u03b3\u2010lyase (CSE), and 3\u2010mercaptopyruvate sulfur transferase (MST). Here, we found that CSE and MST\/CAT were present in normal peripheral nerves. Injured static nerves <jats:italic>in vivo<\/jats:italic> up\u2010regulated CSE in Schwann cells during Wallerian degeneration, but CSE was not up\u2010regulated in peripheral axons.<\/jats:p>","DOI":"10.1111\/jnc.12932","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T13:06:35Z","timestamp":1408021595000},"page":"230-242","source":"Crossref","is-referenced-by-count":33,"title":["Hydrogen sulfide is essential for Schwann cell responses to peripheral nerve injury"],"prefix":"10.1111","volume":"132","author":[{"given":"Byung Sun","family":"Park","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurobiology School of Medicine Biomedical Science Institution Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anatomy College of Medicine Korea University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Im Joo","family":"Rhyu","sequence":"additional","affiliation":[{"name":"Department of Anatomy College of Medicine Korea University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology School of Medicine Biomedical Science Institution Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Geun","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery School of Medicine Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngbuhm","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology School of Medicine Biomedical Science Institution Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na Young","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology College of Medicine Dong\u2010A University Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyang","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology School of Medicine Biomedical Science Institution Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00598.2010"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3023fje"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.001513"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2882"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21751"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)02557-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808026200"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.52.070183.001155"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705891104"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01357.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600309"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.104.6.1623"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6878"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.08.025"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.10.118"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.228999"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20761"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4537-10.2011"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.5115\/acb.2011.44.1.41"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.3.986"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5309"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4345"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-226415"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20493"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20894"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.06.001"},{"key":"e_1_2_7_29_1","first-page":"104","article-title":"A new gaseous signaling molecule emerges: cardioprotective role of hydrogen sulfide","volume":"13","author":"Lefer D. J.","year":"2007","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/60.5.411"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010510-100505"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1052fje"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0030316"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.24.11285"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2005.10.003"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200307132"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200803013"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707540"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-013-9537-0"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvp111"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2253"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2371"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-013-0020-y"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90492-8"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.010868"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2060267"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.04.022"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050611"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01181486"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1907"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/371796a0"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.01.041"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2073"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-8669com"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0211hyp"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0498-382"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1139\/y03-077"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.12932","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.12932","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.12932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T17:05:43Z","timestamp":1696266343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.12932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,6]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/jnc.12932"],"URL":"https:\/\/doi.org\/10.1111\/jnc.12932","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,6]]}}}