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We then identified a novel frameshift mutation in <jats:italic>LIN7B<\/jats:italic> in another ASD patient. Since <jats:italic>LIN7B<\/jats:italic> encodes a scaffold protein essential for neuronal function, we analyzed the role of Lin\u20107B in the development of cerebral cortex. Acute knockdown of Lin\u20107B with <jats:italic>in utero<\/jats:italic> electroporation caused a delay in neuronal migration during corticogenesis. When Lin\u20107B was knocked down in cortical neurons in one hemisphere, their axons failed to extend efficiently into the contralateral hemisphere after leaving the corpus callosum. Meanwhile, enhanced expression of Lin\u20107B had no effects on both cortical neuron migration and axon growth. Notably, silencing of Lin\u20107B did not affect the proliferation of neuronal progenitors and stem cells. Taken together, Lin\u20107B was found to play a pivotal role in corticogenesis through the regulation of excitatory neuron migration and interhemispheric axon growth, while further analyses are required to directly link functional defects of Lin\u20107B to ASD pathophysiology.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc12943-fig-0006-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><jats:p>Lin\u20107 plays a pivotal role as a scaffold protein in synaptic development and plasticity. Based on genetic analyses we identified mutations in LIN\u20107B gene in some ASD (autism\u2010spectrum disorder) patients. Functional defects in Lin\u20107B caused abnormal neuronal migration and interhemispheric axon growth during mouse brain development. Thus, functional deficiency in Lin\u20107B could be implicated in clinical phenotypes in some ASD patients through bringing about abnormal cortical architecture.<\/jats:p>","DOI":"10.1111\/jnc.12943","type":"journal-article","created":{"date-parts":[[2014,9,6]],"date-time":"2014-09-06T07:41:23Z","timestamp":1409989283000},"page":"61-69","source":"Crossref","is-referenced-by-count":19,"title":["Role of an adaptor protein Lin\u20107B in brain development: possible involvement in autism spectrum disorders"],"prefix":"10.1111","volume":"132","author":[{"given":"Makoto","family":"Mizuno","sequence":"first","affiliation":[{"name":"Department of Molecular Neurobiology Institute for Developmental Research Aichi Human Service Center Kasugai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jichi Medical University Tochigi 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