{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:43:00Z","timestamp":1778744580398,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T00:00:00Z","timestamp":1424822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["23659091"],"award-info":[{"award-number":["23659091"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clustered protocadherins (cPcdhs) comprising <jats:styled-content style=\"fixed-case\">cP<\/jats:styled-content>cdh\u2010\u03b1, \u2010\u03b2, and \u2010\u03b3, encode a large family of cadherin\u2010like cell\u2010adhesion molecules specific to neurons. Impairment of <jats:styled-content style=\"fixed-case\">cP<\/jats:styled-content>cdh\u2010\u03b1 results in abnormal neuronal projection patterns in specific brain areas. To elucidate the role of <jats:styled-content style=\"fixed-case\">cP<\/jats:styled-content>cdh\u2010\u03b1 in retinogeniculate projections, we investigated the morphological patterns of retinogeniculate terminals in the lateral geniculate (LG) nucleus of mice with impaired <jats:styled-content style=\"fixed-case\">cP<\/jats:styled-content>cdh\u2010\u03b1. We found huge aggregated retinogeniculate terminals in the dorsal LG nucleus, whereas no such aggregated terminals derived from the retina were observed in the olivary pretectal nucleus and the ventral LG nucleus. These aggregated terminals appeared between P10 and P14, just before eye opening and at the beginning of the refinement stage of the retinogeniculate projections. Reduced visual acuity was observed in adult mice with impaired <jats:styled-content style=\"fixed-case\">cP<\/jats:styled-content>cdh\u2010\u03b1, whereas the orientation selectivity and direction selectivity of neurons in the primary visual cortex were apparently normal. These findings suggest that <jats:styled-content style=\"fixed-case\">cP<\/jats:styled-content>cdh\u2010\u03b1 is required for adequate spacing of retinogeniculate projections, which may be essential for normal development of visual acuity.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc13053-fig-0005-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><jats:p>Clustered protocadherin\u2010\u03b1 (cPcdh\u2010\u03b1) is a family of cadherin\u2010like cell\u2010adhesion molecules specifically expressed in the brain. We revealed that impairment of cPcdh\u2010\u03b1 causes aggregation of fine retinogeniculate terminals in the dorsal lateral geniculate nucleus (LGd), and leads to impaired visual acuity in mice.<\/jats:p>","DOI":"10.1111\/jnc.13053","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T05:37:27Z","timestamp":1423028247000},"page":"66-72","source":"Crossref","is-referenced-by-count":23,"title":["Impaired clustered protocadherin\u2010\u03b1 leads to aggregated retinogeniculate terminals and impaired visual acuity in mice"],"prefix":"10.1111","volume":"133","author":[{"given":"Reiko","family":"Meguro","sequence":"first","affiliation":[{"name":"Division of Neurobiology and Anatomy Graduate School of Medical and Dental Sciences Niigata University Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Hishida","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology Brain Research Institute 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