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Ca<jats:sup>2+<\/jats:sup> influx via L\u2010type Ca<jats:sup>2+<\/jats:sup>\u2010channels is involved in reaching threshold potential for <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> firing, and is responsible for activation of <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content>\u2010channels contributing to <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\u2010repolarization and afterhyperpolarization, whereas P\/Q\u2010type Ca<jats:sup>2+<\/jats:sup>\u2010channels are involved only in the repolarization phase. <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content>\u2010channels carry total outward current during <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\u2010repolarization. Blockade of L\u2010type Ca<jats:sup>2+<\/jats:sup>\u2010channels reduces <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content>\u2010current ~60%, whereas blockade of N\u2010 or P\/Q\u2010type produces little effect. This study demonstrates that Ca<jats:sup>2+<\/jats:sup> influx through L\u2010type Ca<jats:sup>2+<\/jats:sup>\u2010channels plays a key role in modulating the threshold potential from <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>s <jats:italic>in\u00a0situ<\/jats:italic>.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc13055-fig-0007-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\nThis study demonstrates that Ca<jats:sup>2+<\/jats:sup> influx through L\u2010type Ca<jats:sup>2+<\/jats:sup> channels plays a key role in modulating the threshold potential for action potential firing and activating BK channels contributing to repolarization and afterhyperpolarization from rat adrenal chromaffin cells <jats:italic>in\u00a0situ<\/jats:italic>.\n<\/jats:p>","DOI":"10.1111\/jnc.13055","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T11:09:52Z","timestamp":1423825792000},"page":"511-521","source":"Crossref","is-referenced-by-count":19,"title":["Different contributions of calcium channel subtypes to electrical excitability of chromaffin cells in rat adrenal slices"],"prefix":"10.1111","volume":"133","author":[{"given":"Elisa","family":"Albi\u00f1ana","sequence":"first","affiliation":[{"name":"Departament of Pharmacology and Therapeutics University Aut\u00f3noma de Madrid Madrid Spain"},{"name":"Instituto Te\u00f3filo Hernando University Aut\u00f3noma de Madrid Madrid Spain"},{"name":"Facultad de Medicina University Aut\u00f3noma de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Segura\u2010Chama","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n de Medicina Experimental 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