{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:00:51Z","timestamp":1771635651419,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81160168"],"award-info":[{"award-number":["81160168"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have shown that fastigial nucleus stimulation (<jats:styled-content style=\"fixed-case\">FNS<\/jats:styled-content>) reduces tissue damage resulting from focal cerebral ischemia. Although the mechanisms of neuroprotection induced by <jats:styled-content style=\"fixed-case\">FNS<\/jats:styled-content> are not entirely understood, important data have been presented in the past two decades. Micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s) are a newly discovered group of non\u2010coding small <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> molecules that negatively regulate target gene expression and are involved in the regulation of cell proliferation and cell apoptosis. To date, no studies have demonstrated whether mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s can serve as mediators of the brain's response to <jats:styled-content style=\"fixed-case\">FNS<\/jats:styled-content>, which leads to endogenous neuroprotection. Therefore, this study investigated the profiles of <jats:styled-content style=\"fixed-case\">FNS<\/jats:styled-content>\u2010mediated mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s. Using a combination of deep sequencing and microarray with computational analysis, we identified a novel mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> in the rat ischemic cortex after 1\u00a0h of <jats:styled-content style=\"fixed-case\">FNS<\/jats:styled-content>. This novel mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>\u20103p\u20103469_406), herein referred to as rno\u2010miR\u2010676\u20101, was upregulated in rats with cerebral ischemia after <jats:styled-content style=\"fixed-case\">FNS<\/jats:styled-content>. <jats:italic>In vivo<\/jats:italic> observations indicate that this novel mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> may have antiapoptotic effects and contribute to neuroprotection induced by <jats:styled-content style=\"fixed-case\">FNS<\/jats:styled-content>. Our study provides a better understanding of neuroprotection induced by <jats:styled-content style=\"fixed-case\">FNS<\/jats:styled-content>.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc13094-fig-0006-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\nMicroRNA (miRNA) is defined as a small non\u2010coding RNA that fulfills both the expression and biogenesis criteria. Here, we describe a novel miRNA in the rat ischemic cortex expressed after 1\u00a0h of fastigial nucleus stimulation (FNS). The miRNA was functionally characterized by secondary structure, quantitative expression, the conservation analysis, target gene analysis, and biological functions. We consider rno\u2010miR\u2010676\u20101 to be a true microRNA and present evidence for its neuroprotective effects exerted after induction by FNS.\n<\/jats:p>","DOI":"10.1111\/jnc.13094","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T02:45:19Z","timestamp":1426646719000},"page":"926-934","source":"Crossref","is-referenced-by-count":19,"title":["Fastigial nucleus stimulation regulates neuroprotection via induction of a novel micro<scp>RNA<\/scp>, rno\u2010miR\u2010676\u20101, in middle cerebral artery occlusion rats"],"prefix":"10.1111","volume":"133","author":[{"given":"Xiao\u2010Min","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital Guangxi Medical University Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital Guangxi Medical 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