{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:38:25Z","timestamp":1791607105885,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T00:00:00Z","timestamp":1433894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific Technique Research Promotion Program for Agriculture, Forestry and Food Industry"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Amyloid\u2010\u03b2 peptide (A\u03b2), especially its oligomeric form, is believed to play an important role in the pathogenesis of Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>). To this end, the binding of A\u03b2 oligomer to cellular prion protein (PrP<jats:sup>C<\/jats:sup>) plays an important role in synaptic dysfunction in a mouse model of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. Here, we have screened for compounds that inhibit A\u03b2 oligomer binding to Pr<jats:styled-content style=\"fixed-case\">P<jats:sup>C<\/jats:sup><\/jats:styled-content> from medicines already used clinically (Mizushima Approved Medicine Library 1), and identified dextran sulfate sodium (<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>) as a candidate. In a cell\u2010free assay, <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content> inhibited A\u03b2 oligomer binding to Pr<jats:styled-content style=\"fixed-case\">P<jats:sup>C<\/jats:sup><\/jats:styled-content> but not to ephrin receptor B2, another endogenous receptor for A\u03b2 oligomers, suggesting that the drug's action is specific to the binding of A\u03b2 oligomer to Pr<jats:styled-content style=\"fixed-case\">P<jats:sup>C<\/jats:sup><\/jats:styled-content>. Dextran on the other hand did not affect this binding. <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content> also suppressed A\u03b2 oligomer binding to cells expressing Pr<jats:styled-content style=\"fixed-case\">P<jats:sup>C<\/jats:sup><\/jats:styled-content> but not to control cells. Furthermore, while incubation of mouse hippocampal slices with A\u03b2 oligomers inhibited the induction of long\u2010term potentiation, simultaneous treatment with <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content> restored the long\u2010term potentiation. As <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content> has already been approved for use in patients with hypertriglyceridemia, and its safety in humans has been confirmed, we propose further analysis of this drug as a candidate for <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> treatment.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc13166-fig-0005-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><jats:p>Amyloid\u2010\u03b2 peptide (A\u03b2) oligomer\u2010binding to cellular prion protein (PrP<jats:sup>C<\/jats:sup>) is important in synaptic dysfunction in Alzheimer's disease (AD). We found here that dextran sulfate sodium (DSS) inhibits A\u03b2 oligomer binding to PrP<jats:sup>C<\/jats:sup>. Simultaneous treatment of hippocampal slices with DSS restored long\u2010term potentiation (LTP) in the presence of A\u03b2 oligomers. Since DSS has already been approved for clinical use, we propose this drug is a candidate drug for AD treatment.<\/jats:p>","DOI":"10.1111\/jnc.13166","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T09:28:51Z","timestamp":1431422931000},"page":"611-617","source":"Crossref","is-referenced-by-count":11,"title":["Dextran sulfate sodium inhibits amyloid\u2010\u03b2 oligomer binding to cellular prion protein"],"prefix":"10.1111","volume":"134","author":[{"given":"Takahiro","family":"Aimi","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Keio University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Keio University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Keio University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Mizushima","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Keio University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3028"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.10.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.21.6.817"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-11-130"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09635"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00464"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.65.6_suppl_3.S25"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.423954"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1341"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0395-10.2010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.584342"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002369"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.61.67"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07761"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-7-561"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70119-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.149.61"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3214-13.2013"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2583"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.400358"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1782"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.04.034"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3178"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.06.036"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/416535a"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.13166","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.13166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.13166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:27:32Z","timestamp":1696224452000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.13166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,10]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/jnc.13166"],"URL":"https:\/\/doi.org\/10.1111\/jnc.13166","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,10]]}}}