{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:01:14Z","timestamp":1769547674402,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Aix-Marseille Universit\u00e9"},{"DOI":"10.13039\/501100007545","name":"Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire de l'Environnement et du Travail","doi-asserted-by":"crossref","award":["EST-2008\/1\/47\/STRUBE"],"award-info":[{"award-number":["EST-2008\/1\/47\/STRUBE"]}],"id":[{"id":"10.13039\/501100007545","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004793","name":"Minist\u00e8re de l'Education Nationale, de l'Enseignement Sup\u00e9rieur et de la Recherche","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004793","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Besides the well\u2010described inflammatory and dysfunction effects on the respiratory tract, accumulating evidence indicates that ozone (O<jats:sub>3<\/jats:sub>) exposure also affects central nervous system functions. However, the mechanisms through which O<jats:sub>3<\/jats:sub> exerts toxic effects on the brain remain poorly understood. We previously showed that O<jats:sub>3<\/jats:sub> exposure caused a neuronal activation in regions of the rat nucleus tractus solitarii (<jats:styled-content style=\"fixed-case\">NTS<\/jats:styled-content>) overlapping terminal fields of vagal lung afferents. Knowing that O<jats:sub>3<\/jats:sub> exposure can impact astrocytic protein expression, we decided to investigate whether it may induce astroglial cellular alterations in the <jats:styled-content style=\"fixed-case\">NTS<\/jats:styled-content>. Using electron microscopy and immunoblot techniques, we showed that in O<jats:sub>3<\/jats:sub>\u2010exposed animals, the astrocytic coverage of <jats:styled-content style=\"fixed-case\">NTS<\/jats:styled-content> glutamatergic synapses was 19% increased while the astrocyte volume fraction and membrane density were not modified. Moreover, the expression of glial fibrillary acidic protein and S100\u03b2, which are known to be increased in reactive astroglia, did not change. These results indicate that O<jats:sub>3<\/jats:sub> inhalation induces a glial plasticity that is restricted to the peri\u2010synaptic coverage without overall astroglial activation. Taken together, these findings, along with our previous observations, support the conclusion that O<jats:sub>3<\/jats:sub>\u2010induced pulmonary inflammation results in a specific activation of vagal lung afferents rather than non\u2010specific overall brain alterations mediated by blood\u2010borne agents.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc13193-fig-0005-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\nExposure to ozone, a major atmospheric pollutant, induces an increase in the glial coverage of neurons that is restricted to peri\u2010synaptic compartments. This observation does not support the view that the ozone\u2010induced neuronal disorders are related to non\u2010specific overall brain alterations. It rather argues for a specific activation of the vagus nerve in response to pulmonary inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.13193","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T14:18:52Z","timestamp":1434550732000},"page":"857-864","source":"Crossref","is-referenced-by-count":26,"title":["Remodeling of glial coverage of glutamatergic synapses in the rat nucleus tractus solitarii after ozone inhalation"],"prefix":"10.1111","volume":"134","author":[{"given":"Keodavanh","family":"Chounlamountry","sequence":"first","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 CNRS CRN2M UMR 7286 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9n\u00e9dicte","family":"Boyer","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 CNRS CRN2M UMR 7286 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Penalba","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 CNRS CRN2M UMR 7286 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Marie","family":"Fran\u00e7ois\u2010Bellan","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 CNRS CRN2M UMR 7286 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Bosler","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 CNRS CRN2M UMR 7286 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Kessler","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 CNRS CRN2M UMR 7286 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Strube","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9 CNRS CRN2M UMR 7286 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2008.09.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00458-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2003.11.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2009.03.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20613"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/232105"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.06.025"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2015.02.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2008.12.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21135"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00067-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207450108986511"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2010.06.009"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09612"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07267.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040343"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2008.02.001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/08958378.2014.922648"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2010.053165"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.11.024"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1296.008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.1996.0005"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070791"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100957108"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20551"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.02.024"},{"key":"e_1_2_7_28_1","first-page":"827","article-title":"Effects of acute and continuous ozone (O3) exposure on activity\/exploration and social behavior of CD\u20101 mice","volume":"15","author":"Musi B.","year":"1994","journal-title":"Neurotoxicology"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)00410-X"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90118-Q"},{"key":"e_1_2_7_31_1","unstructured":"RasbandW. 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