{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:48:50Z","timestamp":1787806130348,"version":"build-2784847793"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T00:00:00Z","timestamp":1438560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007109","name":"Universit\u00e0 degli Studi di Ferrara","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Abstract<\/jats:title>Converging lines of evidence suggest that paraoxonase\u20101 (PON<\/jats:styled-content>\u20101) may confer protection against inflammatory and oxidative challenge which, in turn, plays a key\u2010role in the onset and progression of dementia. The aim of this study was to evaluate whether serum PON<\/jats:styled-content>\u20101 paraoxonase\/arylesterase activities might predict the clinical conversion of mild cognitive impairment (MCI<\/jats:styled-content>) to late\u2010onset Alzheimer's disease (LOAD<\/jats:styled-content>) or vascular dementia (VAD<\/jats:styled-content>). Serum paraoxonase and arylesterase activities were measured by spectrophotometric assays at baseline in 141 MCI<\/jats:styled-content> patients (median age: 77\u00a0years; interquartile range 71\u201381) and in 78 healthy controls (median age: 76\u00a0years; interquartile range 73\u201379). After 2\u00a0years of follow\u2010up, 86 MCI<\/jats:styled-content> remained stable (MCI<\/jats:styled-content>\/MCI<\/jats:styled-content>), 34 converted to LOAD<\/jats:styled-content> (MCI<\/jats:styled-content>\/LOAD<\/jats:styled-content>), whereas 21 converted to VAD<\/jats:styled-content> (MCI<\/jats:styled-content>\/VAD<\/jats:styled-content>). Baseline arylesterase activity was lower in all MCI<\/jats:styled-content> groups compared with controls (all p<\/jats:italic>\u00a0<\u00a00.01), whereas paraoxonase activity was lower in MCI<\/jats:styled-content>\/VAD<\/jats:styled-content> group compared to controls (p<\/jats:italic>\u00a0<\u00a00.05) and MCI<\/jats:styled-content>\/MCI<\/jats:styled-content> patients (p<\/jats:italic>\u00a0=\u00a00.009). Low paraoxonase and arylesterase activities (I quartile) were associated to higher risk of conversion to VAD<\/jats:styled-content> (OR: 3.74, 95% CI: 1.37\u201310.25 and OR: 3.16, 95% CI: 1.17\u20138.56, respectively). Our results suggest that in MCI<\/jats:styled-content> patients low PON<\/jats:styled-content>\u20101 activity might contribute to identify individuals susceptible to develop vascular dementia.<\/jats:p><\/jats:sec>\nimage<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>Our study showed that in patients with mild cognitive impairment (MCI) low serum levels of paraoxonase\u20101 (PON\u20101) activity is associated with a higher likelihood of developing Vascular Dementia, but not Alzheimer's Disease. The observed connection might be explained by the ability of PON\u20101 to retard low\u2010density lipoprotein (LDL) oxidation, decrease oxidative stress, attenuate inflammation, and increase cholesterol efflux.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.13240","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T15:16:44Z","timestamp":1436887004000},"page":"395-401","source":"Crossref","is-referenced-by-count":49,"title":["Serum paraoxonase and arylesterase activities of paraoxonase\u20101 (PON<\/scp>\u20101), mild cognitive impairment, and 2\u2010year conversion to dementia: A pilot study"],"prefix":"10.1111","volume":"135","author":[{"given":"Carlo","family":"Cervellati","sequence":"first","affiliation":[{"name":"Section\u00a0of Medical Biochemistry, Molecular Biology and Genetics Department of Biomedical and Specialist Surgical Sciences University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Trentini","sequence":"additional","affiliation":[{"name":"Section\u00a0of Medical Biochemistry, Molecular Biology and Genetics Department of Biomedical and Specialist Surgical Sciences University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Romani","sequence":"additional","affiliation":[{"name":"Section\u00a0of Medical Biochemistry, Molecular Biology and Genetics Department of Biomedical and Specialist Surgical Sciences University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Bellini","sequence":"additional","affiliation":[{"name":"Section\u00a0of Medical Biochemistry, Molecular Biology and Genetics Department of Biomedical and Specialist Surgical Sciences University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Bosi","sequence":"additional","affiliation":[{"name":"Section\u00a0of Internal and Cardiopulmonary Medicine Department of Medical Science University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Ortolani","sequence":"additional","affiliation":[{"name":"Section\u00a0of Internal and Cardiopulmonary Medicine Department of Medical Science University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amedeo","family":"Zurlo","sequence":"additional","affiliation":[{"name":"Operative Unit of Geriatrics S. Anna University Hospital Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"Passaro","sequence":"additional","affiliation":[{"name":"Section\u00a0of Internal and Cardiopulmonary Medicine Department of Medical Science University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Seripa","sequence":"additional","affiliation":[{"name":"Geriatric Unit of the IRCCS \u201cCasa Sollievo della Sofferenza\u201d San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Zuliani","sequence":"additional","affiliation":[{"name":"Section\u00a0of Internal and Cardiopulmonary Medicine Department of Medical Science University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317514539541"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1649"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.2.330"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-091723"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5114\/fn.2013.35953"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1041"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043384664"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42946"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.11.1265"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-111940"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205011310040003"},{"key":"e_1_2_7_13_1","first-page":"1049","article-title":"PON\u20101 and ferroxidase activities in older patients with mild cognitive impairment, late onset Alzheimer's disease or vascular dementia","volume":"53","author":"Cervellati C.","year":"2014","journal-title":"Clin. 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