{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:52:44Z","timestamp":1788385964000,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T00:00:00Z","timestamp":1444262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006977","name":"Indiana State Department of Health","doi-asserted-by":"publisher","award":["204200"],"award-info":[{"award-number":["204200"]}],"id":[{"id":"10.13039\/100006977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS073636"],"award-info":[{"award-number":["NS073636"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS073636"],"award-info":[{"award-number":["NS073636"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Abstract<\/jats:title>Acrolein, an endogenous aldehyde, has been shown to be involved in sensory hypersensitivity after rat spinal cord injury (SCI<\/jats:styled-content>), for which the pathogenesis is unclear. Acrolein can directly activate a pro\u2010algesic transient receptor protein ankyrin 1 (TRPA<\/jats:styled-content>1) channel that exists in sensory neurons. Both acrolein and TRPA<\/jats:styled-content>1 mRNA<\/jats:styled-content> are elevated post SCI<\/jats:styled-content>, which contributes to the activation of TRPA<\/jats:styled-content>1 by acrolein and consequently, neuropathic pain. In the current study, we further showed that, post\u2010SCI<\/jats:styled-content> elevation of TRPA<\/jats:styled-content>1 mRNA<\/jats:styled-content> exists not only in dorsal root ganglias but also in both peripheral (paw skin) and central endings of primary afferent nerves (dorsal horn of spinal cord). This is the first indication that pain signaling can be over\u2010amplified in the peripheral skin by elevated expressions of TRPA<\/jats:styled-content>1 following SCI<\/jats:styled-content>, in addition over\u2010amplification previously seen in the spinal cord and dorsal root ganglia. Furthermore, we show that acrolein alone, in the absence of physical trauma, could lead to the elevation of TRPA<\/jats:styled-content>1 mRNA<\/jats:styled-content> at various locations when injected to the spinal cord. In addition, post\u2010SCI<\/jats:styled-content> elevation of TRPA<\/jats:styled-content>1 mRNA<\/jats:styled-content> could be mitigated using acrolein scavengers. Both of these attributes support the critical role of acrolein in elevating TRPA<\/jats:styled-content>1 expression through gene regulation. Taken together, these data indicate that acrolein is likely a critical causal factor in heightening pain sensation post\u2010SCI<\/jats:styled-content>, through both the direct binding of TRPA<\/jats:styled-content>1 receptor, and also by boosting the expression of TRPA<\/jats:styled-content>1. Finally, our data also further support the notion that acrolein scavenging may be an effective therapeutic approach to alleviate neuropathic pain after SCI.<\/jats:p><\/jats:sec>\nimage<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>We propose that the trauma\u2010mediated elevation of acrolein causes neuropathic pain through at least two mechanisms: acrolein stimulates the production of transient receptor protein ankyrin 1 (TRPA1) in both central and peripheral locations, and it activates TRPA1 channels directly. Therefore, acrolein appears to be a critical factor in the pathogenesis of post\u2010SCI sensory hypersensitivity, becoming a novel therapeutic target to relieve both acute and chronic post\u2010SCI neuropathic pain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.13352","type":"journal-article","created":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T08:46:45Z","timestamp":1442220405000},"page":"987-997","source":"Crossref","is-referenced-by-count":50,"title":["Acrolein contributes to TRPA<\/scp>1 up\u2010regulation in peripheral and central sensory hypersensitivity following spinal cord injury"],"prefix":"10.1111","volume":"135","author":[{"given":"Jonghyuck","family":"Park","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences College of Veterinary Medicine Purdue University West Lafayette Indiana USA"},{"name":"Weldon School of Biomedical Engineering Purdue University West Lafayette Indiana 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