{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:03:54Z","timestamp":1791270234553,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Spanish Government"},{"name":"Andalusian Government"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Despite the different animal models of Parkinson's disease developed during the last years, they still present limitations modelling the slow and progressive process of neurodegeneration. Here, we undertook a histological, neurochemical and behavioural analysis of a new chronic parkinsonian mouse model generated by the subcutaneous administration of low doses of <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content> (20\u00a0mg\/kg, 3 times per week) for 3\u00a0months, using both young adult and aged mice. The <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content>\u2010induced nigrostriatal neurodegeneration was progressive and was accompanied by a decrease in striatal dopamine levels and motor impairment. We also demonstrated the characteristic neuroinflammatory changes (microglial activation and astrogliosis) associated with the neurodegenerative process. Aged animals showed both a faster time course of neurodegeneration and an altered neuroinflammatory response. The long\u2010term systemic application of low <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content> doses did not induce any increase in mortality in either young adult or aged mice and better resembles the slow evolution of the neurodegenerative process. This treatment could be useful to model different stages of Parkinson's disease, providing a better understanding of the pathophysiology of the disease and facilitating the testing of both protective and restorative treatments.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc13409-fig-0008-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\nHere, we show a new chronic and progressive parkinsonian mouse model, in young and aged mice. This model produces a stable degeneration of the dopaminergic nigrostriatal pathway, continuous neuroinflammatory reaction and motor deficits. Aged animals showed a faster neurodegeneration and an altered neuroinflammatory response. This treatment could be useful to model different stages of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and to test both protective and restorative therapeutic approaches.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.13409","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T08:45:45Z","timestamp":1445849145000},"page":"373-387","source":"Crossref","is-referenced-by-count":89,"title":["Chronic and progressive Parkinson's disease <scp>MPTP<\/scp> model in adult and aged mice"],"prefix":"10.1111","volume":"136","author":[{"given":"Ana B.","family":"Mu\u00f1oz\u2010Manchado","sequence":"first","affiliation":[{"name":"Instituto de Biomedicina de Sevilla\u2010IBiS HUVR\/Universidad de Sevilla\/CSIC Sevilla Spain"},{"name":"Departamento de Fisiolog\u00eda M\u00e9dica y Biof\u00edsica Universidad de Sevilla Sevilla Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) 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