{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:52:06Z","timestamp":1788385926480,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T00:00:00Z","timestamp":1463356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006977","name":"Indiana State Department of Health","doi-asserted-by":"publisher","award":["204200"],"award-info":[{"award-number":["204200"]}],"id":[{"id":"10.13039\/100006977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS073636"],"award-info":[{"award-number":["NS073636"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["13430722100"],"award-info":[{"award-number":["13430722100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p>Currently there are no effective therapies available for the excruciating neuropathic pain that develops after spinal cord injuries (<jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>). As such, a great deal of effort is being put into the investigation of novel therapeutic targets that can alleviate this pain. One such target is acrolein, a highly reactive aldehyde produced as a byproduct of oxidative stress and inflammation that is capable of activating the transient receptor potential ankyrin 1 (<jats:styled-content style=\"fixed-case\">TRPA<\/jats:styled-content>1) cation channel, known to be involved in the transmission and propagation of chronic neuropathic pain. One anti\u2010acrolein agent, hydralazine, has already been shown to reduce neuropathic pain behaviors and offer neuroprotection after <jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>. This study investigates another acrolein scavenger, phenelzine, for its possible role of alleviating sensory hypersensitivity through acrolein suppression. The results show that phenelzine is indeed capable of attenuating neuropathic pain behaviors in acute, delayed, and chronic administration schedules after injury in a rat model of <jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>. In addition, upon the comparison of hydralazine to phenelzine, both acrolein scavengers displayed a dose\u2010dependent response in the reduction of acrolein <jats:italic>in\u00a0vivo<\/jats:italic>. Finally, phenelzine proved capable of providing locomotor function recovery and neuroprotection of spinal cord tissue when administered immediately after injury for 2\u00a0weeks. These results indicate that phenelzine may be an effective treatment for neuropathic pain after <jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content> and likely a viable alternative to hydralazine.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc13639-fig-0010-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>We have shown that phenelzine can attenuate neuropathic pain behavior in acute, delayed, and chronic administration in post\u2010<jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content> rats. This was accompanied by a dose\u2010dependent reduction in an acrolein metabolite in urine and an acrolein adduct in spinal cord tissue, and the suppression of <jats:styled-content style=\"fixed-case\">TRPA<\/jats:styled-content>1 over\u2010expression in central and peripheral locations post\u2010trauma. Acrolein scavenging might be a novel therapeutic strategy to reduce post\u2010<jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content> neuropathic pain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.13639","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T18:40:50Z","timestamp":1460313650000},"page":"328-338","source":"Crossref","is-referenced-by-count":64,"title":["Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury"],"prefix":"10.1111","volume":"138","author":[{"given":"Zhe","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Orthopedics Rui\u2010Jin Hospital School of Medicine Shanghai Jiao\u2010tong University Institute of Trauma and Orthopedics Shanghai China"},{"name":"Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese\u2010Western Medicine Shanghai Institute of Traumatology and Orthopedics Rui\u2010Jin Hospital Shanghai Jiao\u2010tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonghyuck","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences College of Veterinary Medicine Purdue University West Lafayette IN USA"},{"name":"Weldon School of Biomedical Engineering Purdue University West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breanne","family":"Butler","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Acosta","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences College of Veterinary Medicine Purdue University West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"Vega\u2010Alvarez","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences College of Veterinary Medicine Purdue University West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences College of Veterinary Medicine Purdue University West Lafayette IN USA"},{"name":"Weldon School of Biomedical Engineering Purdue University West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences College of Veterinary Medicine Purdue University West Lafayette IN USA"},{"name":"Weldon School of Biomedical Engineering Purdue University West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"McCain","sequence":"additional","affiliation":[{"name":"Purdue Translational Pharmacology Bindley Bioscience Center Purdue University West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenpeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University West Lafayette IN USA"},{"name":"Department of Chemistry Purdue University West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Rui\u2010Jin Hospital School of Medicine Shanghai Jiao\u2010tong University Institute of Trauma and Orthopedics Shanghai China"},{"name":"Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese\u2010Western Medicine Shanghai Institute of Traumatology and Orthopedics Rui\u2010Jin Hospital Shanghai Jiao\u2010tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyi","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences College of Veterinary Medicine Purdue University West Lafayette IN USA"},{"name":"Weldon School of Biomedical Engineering Purdue University West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,16]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"206","article-title":"Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine: a review","volume":"17","author":"Baker G. B.","year":"1992","journal-title":"J. Psychiatry Neurosci."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047988"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1995.12.1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp322"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.018168"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1179\/rer.2000.5.1.47"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1978.tb00853.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0720751.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.117.4.361"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12500"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(91)90192-6"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020221919154"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0130OC"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.08.026"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38724"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0704(18)30408-1"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06395.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05622.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.05002.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2008.12.010"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04969.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/b408796h"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4800.27"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00390-3"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12138"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.11.018"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20862"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00235-9"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1980.229"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-005-2602-7"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.06.011"},{"key":"e_1_2_8_37_1","unstructured":"Pfizer Inc. 2009 Pfizer Inc New York NY"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408440591002183"},{"key":"e_1_2_8_39_1","first-page":"199","article-title":"Long term propranolol and hydralazine in hypertension","volume":"32","author":"Pandit R. B.","year":"1984","journal-title":"J. Assoc. Physicians India"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.131564"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12628"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13352"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02805970"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(01)00012-2"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610010105"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-198512000-00005"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2007.0502"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1806-12.2013"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1980.238"},{"key":"e_1_2_8_50_1","first-page":"22","article-title":"The role of acrolein in spinal cord injury","volume":"2","author":"Shi R.","year":"2006","journal-title":"Applied Neurol."},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00457-8"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100217"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07226.x"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2015.1021696"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.211"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1999.tb00212.x"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200700412"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.06.042"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2013.02.005"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.09.003"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(94)90352-2"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.2888"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.13639","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.13639","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.13639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T17:58:38Z","timestamp":1696269518000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.13639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,16]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/jnc.13639"],"URL":"https:\/\/doi.org\/10.1111\/jnc.13639","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,16]]}}}