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The role of striatal astrocytes in the striatal initiation of the dopaminergic degeneration is little known. This work was aimed at studying the astrocytic response to the dopaminergic denervation of the striatum. The injection of 6\u2010hydroxydopamine (25\u00a0\u03bcg) in the lateral ventricle of adult Sprague\u2013Dawley rats induced a fast (4\u00a0h) and selective (unaccompanied by unspecific lesions of striatal tissue or microgliosis) degeneration of the dopaminergic innervation of the striatum which was followed by a selective astrocytosis unaccompanied by microgliosis. This astrocytosis was severe and had a specific profile which included some (e.g. up\u2010regulation of glial fibrillary acidic protein,<jats:styled-content style=\"fixed-case\">GS<\/jats:styled-content>, S100\u03b2,<jats:styled-content style=\"fixed-case\">NDRG<\/jats:styled-content>2, vimentin) but not all (e.g. astrocytic proliferation or differentiation from<jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content>2 cells, astrocytic scars, microgliosis) the characteristics observed after the non\u2010selective lesion of the striatum. This astrocytosis is similar to those observed in the parkinsonian striatum and, because it is was unaccompanied by changes in other striatal cells (e.g. by microgliosis), it may be suitable to study the role of striatal astrocytes during the dopaminergic denervation which characterizes the first stages of Parkinson's disease.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc13684-fig-0007-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>The dopaminergic denervation of the striatum induced a severe astrogliosis with a specific profile which included some (e.g. up\u2010regulation of<jats:styled-content style=\"fixed-case\">GFAP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">GS<\/jats:styled-content>, S100\u03b2,<jats:styled-content style=\"fixed-case\">NDRG<\/jats:styled-content>2, vimentin) but not all (e.g. astrocytic proliferation or differentiation from<jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content>2 cells, astrocytic scars, microgliosis) the characteristics observed after the non\u2010selective striatal lesions. This response may help to understand the role of striatal astrocytes during the dopaminergic denervation which characterizes the first stages of<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><jats:p><jats:bold>Cover Image<\/jats:bold>for this issue: doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1111\/jnc.13336\">10.1111\/jnc.13336<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.13684","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T04:06:42Z","timestamp":1464322002000},"page":"81-95","source":"Crossref","is-referenced-by-count":51,"title":["The astrocytic response to the dopaminergic denervation of the striatum"],"prefix":"10.1111","volume":"139","author":[{"given":"Ingrid","family":"Morales","sequence":"first","affiliation":[{"name":"Laboratory of Neurobiology and Experimental Neurology Department of Physiology Faculty of Medicine University of 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