{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:04:56Z","timestamp":1760853896999,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:00:00Z","timestamp":1474416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alterations of the cerebrospinal fluid (CSF) composition are useful clinical diagnostic tools as well as a source of candidates for new biomarkers of neurodegenerative disorders. This Editorial highlights a study by Rodrigues and colleagues in which the authors try to establish Tau as a new biomarker for Huntington\u00b4s disease (HD). The study confirmed in two independent, age\u2010controlled patient populations at various disease stages, asymptomatic mutation carriers and healthy controls, that CSF total Tau concentrations in HD gene mutation carriers are increased compared with healthy controls. This is a strong evidence that CSF total Tau concentration is associated with phenotypic variability in HD.<\/jats:p><jats:p><jats:bold>Read the highlighted article<\/jats:bold> \u2018Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington's disease\u2019 on page <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/dx.doi.org\/10.1111\/jnc.13719\">22<\/jats:ext-link>.<\/jats:p>","DOI":"10.1111\/jnc.13762","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T05:22:45Z","timestamp":1474435365000},"page":"9-10","source":"Crossref","is-referenced-by-count":5,"title":["Is there a role of Tau in Huntington\u2032s disease?"],"prefix":"10.1111","volume":"139","author":[{"given":"Inga","family":"Zerr","sequence":"first","affiliation":[{"name":"Department of Neurology University Medicine G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"B\u00e4hr","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medicine G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,21]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3810"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.06.010"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000063313.57292.00"},{"issue":"2","key":"e_1_2_3_5_1","article-title":"Tau pathology in Huntington's disease: a brief in\u00a0vivo PET\u2010imaging report","volume":"31","author":"Giehl K.","year":"2016","journal-title":"Mov. 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