{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:47:41Z","timestamp":1768441661165,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T00:00:00Z","timestamp":1476144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Interdisciplinary Center for Clinical Research (IZKF) Aachen","award":["N7-1"],"award-info":[{"award-number":["N7-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The death receptor Fas\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>95 mediates apoptotic cell death in response to external stimuli. In neurons, Fas\u2010induced apoptosis is prevented by Fas\u2010apoptotic inhibitory molecule 2 (Faim2). Mice lacking Faim2 showed increased neurodegeneration in animal models of stroke and bacterial meningitis. We therefore tested the relevance of Faim2 in a classical animal model of Parkinson disease and determined the toxicity of 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (<jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content>) in Faim2\u2010deficient mice. Without <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content> treatment, there was no difference in the dopaminergic system between Faim2\u2010deficient mice and control mice. <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content> was applied i.p. in doses of 30\u00a0mg per kg on five consecutive days. Fourteen\u00a0days after the last <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content> injection, the number of dopaminergic neurons in the lateral <jats:italic>substantia nigra<\/jats:italic>, assayed by stereological counting, was reduced by 39% in control mice and 53% in Faim2\u2010deficient mice. The density of dopaminergic fibers in the dorsal striatum was reduced by 36% in control mice and 69% in Faim2\u2010deficient mice, in the ventral striatum 44% in control mice and 76% in Faim2\u2010deficient mice. Fiber density recovered at 90\u00a0days after <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content> with similar density in both groups. Striatal catecholamine levels were reduced by 81\u201384% in both groups and recovered at 90\u00a0days. Faim2 expression was documented in mouse midbrain using quantitative reverse transcription\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">qRT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>) and found decreased after <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content> administration. Taken together, our findings demonstrate increased degeneration of dopaminergic neurons with Faim2 deficiency, indicating that Fas\u2010induced apoptosis contributes to cell death in the <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content> mouse model. Along with the decreased expression of Faim2 after <jats:styled-content style=\"fixed-case\">MPTP<\/jats:styled-content>, this finding indicates that boosting Faim2 function might represent a therapeutic strategy for Parkinson disease.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc13847-fig-0008-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.13847","type":"journal-article","created":{"date-parts":[[2016,9,17]],"date-time":"2016-09-17T07:48:52Z","timestamp":1474098532000},"page":"848-857","source":"Crossref","is-referenced-by-count":18,"title":["Mice lacking Faim2 show increased cell death in the <scp>MPTP<\/scp> mouse model of Parkinson disease"],"prefix":"10.1111","volume":"139","author":[{"given":"Daniel","family":"Komnig","sequence":"first","affiliation":[{"name":"Department of Neurology RWTH University Aachen Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg B.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH University Aachen Aachen Germany"},{"name":"JARA\u2010Institute Molecular Neuroscience and Neuroimaging Forschungszentrum J\u00fclich GmbH and RWTH Aachen University Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Reich","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH University Aachen Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn H.","family":"Falkenburger","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH University Aachen Aachen Germany"},{"name":"JARA\u2010Institute Molecular Neuroscience and Neuroimaging Forschungszentrum J\u00fclich GmbH and RWTH Aachen University Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1700-05.2005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(73)90175-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-03-01714.1995"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00568-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb916"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00581-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-24-09126.2000"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.5.2283"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04767.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.2000.00267.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws054"},{"key":"e_1_2_8_13_1","volume-title":"The mouse brain in stereotaxic coordinates","author":"Franklin K. 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