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Despite advancements in clinical management, treatment of patients with <jats:styled-content style=\"fixed-case\">AIDP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> and its chronic variant <jats:styled-content style=\"fixed-case\">CIDP<\/jats:styled-content> remains palliative and relies on the use of non\u2010specific immunemodulating therapies. Our laboratory has previously reported that therapeutic administration of statins safely attenuates the clinical severity of experimental autoimmune neuritis (<jats:styled-content style=\"fixed-case\">EAN<\/jats:styled-content>), a well\u2010characterized animal model of <jats:styled-content style=\"fixed-case\">AIDP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>, by restricting the migration of autoreactive leukocytes across peripheral nerve microvascular endoneurial endothelial cells that form the blood\u2013nerve barrier. Despite these advancements, the clinical application of systemically administered statins for the management of inflammatory disorders remains controversial as a result of disappointingly inconclusive phase trials. Here, poly(lactic\u2010co\u2010glycolic) acid (<jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content>) nanoparticles were evaluated as an alternative strategy by which to locally administer statins for the management of <jats:styled-content style=\"fixed-case\">EAN<\/jats:styled-content>. When tested <jats:italic>in\u00a0vitro<\/jats:italic>, lovastatin\u2010encapsulating <jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content> nanoparticles elicited a marked increase in RhoB <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> content in peripheral nerve microvascular endoneurial endothelial cells, similar to cells treated with activated unencapsulated lovastatin. Unilateral peri\u2010neural administration of lovastatin\u2010encapsulating <jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content> nanoparticles, but not empty nanoparticles, to na\u00efve Lewis rats similarly enhanced RhoB <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> content in adjacent nerve and muscle tissue. When administered in this manner, serum levels of lovastatin were below the level of detection. Bilateral peri\u2010neural administration of lovastatin\u2010encapsulating <jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content> nanoparticles to <jats:styled-content style=\"fixed-case\">EAN<\/jats:styled-content>\u2010induced Lewis rats significantly attenuated <jats:styled-content style=\"fixed-case\">EAN<\/jats:styled-content> clinical severity while protecting against <jats:styled-content style=\"fixed-case\">EAN<\/jats:styled-content>\u2010induced peripheral nerve morphological and functional deficits. This study provides the first proof\u2010of\u2010concept approach for the application of a nanoparticle\u2010based local drug delivery platform for the management of inflammatory demyelinating diseases, including <jats:styled-content style=\"fixed-case\">AIDP<\/jats:styled-content>\/GBS.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc13892-fig-0007-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.13892","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T16:23:26Z","timestamp":1478622206000},"page":"334-346","source":"Crossref","is-referenced-by-count":23,"title":["Attenuation of experimental autoimmune neuritis with locally administered lovastatin\u2010encapsulating poly(lactic\u2010co\u2010glycolic) acid nanoparticles"],"prefix":"10.1111","volume":"140","author":[{"given":"Kelly A.","family":"Langert","sequence":"first","affiliation":[{"name":"Research Service Department of Veterans Affairs Edward Hines Jr. VA Hospital Hines Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruktawit","family":"Goshu","sequence":"additional","affiliation":[{"name":"Research Service Department of Veterans Affairs Edward Hines Jr. VA Hospital Hines Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Evan B.","family":"Stubbs","sequence":"additional","affiliation":[{"name":"Research Service Department of Veterans Affairs Edward Hines Jr. VA Hospital Hines Illinois USA"},{"name":"Program of Neuroscience Stritch School of Medicine Loyola University Chicago Maywood Illinois USA"},{"name":"Department of Ophthalmology Stritch School of Medicine Loyola University Chicago Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.5.1043"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856206775997322"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-9961(02)00007-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns5.12045"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002113"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759091415595726"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62242-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.052282"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.43.100901.140251"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-5001-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000316393.54258.d1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20391"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(99)01639-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-007-0037-0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-1014fje"},{"key":"e_1_2_7_17_1","first-page":"328","article-title":"Experimental allergic neuritis (EAN) as a model for the immune\u2010mediated demyelinating neuropathies","volume":"152","author":"Hahn A. 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