{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:28:54Z","timestamp":1777645734447,"version":"3.51.4"},"reference-count":155,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>In this review, we present our most recent understanding of key biomolecular processes that underlie two motor neuron degenerative disorders, amyotrophic lateral sclerosis, and spinal muscular atrophy. We focus on the role of four multifunctional proteins involved in <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> metabolism (<jats:styled-content style=\"fixed-case\">TDP<\/jats:styled-content>\u201043, <jats:styled-content style=\"fixed-case\">FUS<\/jats:styled-content>, SMN, and Senataxin) that play a causal role in these diseases. Recent results have led to a novel scenario of intricate connections between these four proteins, bringing transcriptome homeostasis into the spotlight as a common theme in motor neuron degeneration. We review reported functional and physical interactions between these four proteins, highlighting their common association with nuclear bodies and small nuclear ribonucleoprotein particle biogenesis and function. We discuss how these interactions are turning out to be particularly relevant for the control of transcription and chromatin homeostasis, including the recent identification of an association between SMN and Senataxin required to ensure the resolution of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> hybrid formation and proper termination by <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> polymerase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. These connections strongly support the existence of common pathways underlying the spinal muscular atrophy and amyotrophic lateral sclerosis phenotype. We also discuss the potential of genome\u2010wide expression profiling, in particular <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> sequencing derived data, to contribute to unravelling the underlying mechanisms. We provide a review of publicly available datasets that have addressed both diseases using these approaches, and highlight the value of investing in cross\u2010disease studies to promote our understanding of the pathways leading to neurodegeneration.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc13945-fig-0004-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.13945","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T07:22:49Z","timestamp":1483600969000},"page":"12-30","source":"Crossref","is-referenced-by-count":23,"title":["Linking amyotrophic lateral sclerosis and spinal muscular atrophy through <scp>RNA<\/scp>\u2010transcriptome homeostasis: a genomics perspective"],"prefix":"10.1111","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0365-6916","authenticated-orcid":false,"given":"Margarida","family":"Gama\u2010Carvalho","sequence":"first","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Ci\u00eancias BioISI \u2013 Biosystems &amp; Integrative Sciences Institute Campo Grande 1749\u2010016 Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"L. Garcia\u2010Vaquero","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Ci\u00eancias BioISI \u2013 Biosystems &amp; Integrative Sciences Institute Campo Grande 1749\u2010016 Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"R. Pinto","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Ci\u00eancias BioISI \u2013 Biosystems &amp; Integrative Sciences Institute Campo Grande 1749\u2010016 Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Besse","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Cote d'Azur CNRS Inserm iBV Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Weis","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology RWTH Aachen University Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Voigt","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH Aachen University Aachen Germany"},{"name":"JARA\u2010Institute Molecular Neuroscience and Neuroimaging Forschungszentrum J\u00fclich GmbH and RWTH Aachen University Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8903-0593","authenticated-orcid":false,"given":"J\u00f6rg B.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH Aachen University Aachen Germany"},{"name":"JARA\u2010Institute Molecular Neuroscience and Neuroimaging Forschungszentrum J\u00fclich GmbH and RWTH Aachen University Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"De Las Rivas","sequence":"additional","affiliation":[{"name":"Cancer Research Center (CiC\u2010IBMCC, CSIC\/USAL\/IBSAL) Consejo Superior de Investigaciones Cient\u00edficas (CSIC) and Universidad de Salamanca (USAL) Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,28]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu864"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.12.018"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp1224"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2014.929148"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12349"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21154"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0480-1"},{"key":"e_1_2_15_9_1","first-page":"359","article-title":"The diverse world of small ribonucleoproteins","volume":"24","author":"Baserga S. J.","year":"1993","journal-title":"Cold Spring Harbor Monograph Archive"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2006.71.001"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000773"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.12.071"},{"key":"e_1_2_15_13_1","first-page":"127","article-title":"Unwinding the role of senataxin in neurodegeneration","volume":"19","author":"Bennett C. L.","year":"2015","journal-title":"Discov Med"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3662"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.029"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318249f697"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.06.015"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.13.2351"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2670"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2016.00007"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1637-06.2006"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12242"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.02.004"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/421054"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3185"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-28"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.20.010403.103738"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201489852"},{"key":"e_1_2_15_29_1","first-page":"777","volume":"136","author":"Cooper T. A.","year":"2009","journal-title":"RNA and disease. Cell"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.156"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.255"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.011"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.01.044"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds205"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi168"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0813128106"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14974"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.13.5915"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.983602"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.16.1.273"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.038919.113"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.057208.116"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.03.003"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.01.017"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.04.004"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000144344.39103.F6"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt222"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng703"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80026-X"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2101"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.02.007"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00098-3"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.09.053"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fob.2013.11.001"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt029"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt262"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2009.24"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3688"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106161200"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4085"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09479"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-009-8054-3"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds174"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11922"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000387"},{"key":"e_1_2_15_66_1","first-page":"800","article-title":"U1 snRNA associates with TFIIH and regulates transcriptional initiation","volume":"9","author":"Kwek K. Y.","year":"2002","journal-title":"Nat. Struct. Biol."},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1166066"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254917"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq137"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3230"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.10.049"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90460-3"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.04.026"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008227107"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab0983"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00725.x"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80367-0"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8528-1"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6307"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq147"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.09.012"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1139"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13588"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21147"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70195-2"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2438"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.255737.114"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3742"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3961"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.12.001"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.7.1177"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1303"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.037804.112"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1134108"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000653"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.6.3584-3596.1995"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.047"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu169"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.152.1.75"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw247"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2779"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3943"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.05.014"},{"key":"e_1_2_15_104_1","first-page":"9711","article-title":"FUS\/TLS contributes to replication\u2010dependent histone gene expression by interaction with U7 snRNPs and histone\u2010specific transcription factors","volume":"43","author":"Raczynska K. D.","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.010"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3584"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3430"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep00603"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/400_2009_4"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2011.09.006"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt835"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000193"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.126003"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023882"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1080\/19491034.2015.1004952"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759091414544472"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3961"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2297"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1963"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.03.006"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12083"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0411-1"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb961"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.04.026"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3167"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.061358"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154584"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.036"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.134"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7171"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200701042"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp278"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.184"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/nass\/nrp124"},{"key":"e_1_2_15_135_1","first-page":"82","volume":"1","author":"Tan A. Y.","year":"2009","journal-title":"The TET Family of Proteins: Functions and Roles in Disease."},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200210"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.11.012"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201202303"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.09.030"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1165942"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt117"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2013.11.003"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr084"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000174472.03292.dd"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10966"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20120058"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.342005"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp157"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.08.025"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.03.014"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1506282112"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.031"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1319280110"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14973"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16469"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2013.04.003"}],"container-title":["Journal of Neurochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjnc.13945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnc.13945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T20:37:32Z","timestamp":1696279052000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jnc.13945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,28]]},"references-count":155,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/jnc.13945"],"URL":"https:\/\/doi.org\/10.1111\/jnc.13945","archive":["Portico"],"relation":{},"ISSN":["0022-3042","1471-4159"],"issn-type":[{"value":"0022-3042","type":"print"},{"value":"1471-4159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,28]]}}}