{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:28:17Z","timestamp":1773757697427,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Antimicrobial peptides are an important part of the innate immune defense in the central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>). The expression of the antimicrobial peptides psoriasin (S100A7) is up\u2010regulated during bacterial meningitis. However, the exact mechanisms induced by psoriasin to modulate glial cell activity are not yet fully understood. Our hypothesis is that psoriasin induced pro\u2010 and anti\u2010inflammatory signaling pathways as well as regenerative factors to contribute in total to a balanced immune response. Therefore, we used psoriasin\u2010stimulated glial cells and analyzed the translocation of the pro\u2010inflammatory transcription factor nuclear factor \u2018kappa\u2010light\u2010chain\u2010enhancer\u2019 of activated B\u2010cells (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u03baB) in murine glial cells and the expression of pro\u2010 and anti\u2010inflammatory mediators by real time <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ELISA<\/jats:styled-content> technique, and western blotting. Furthermore, the relationship between psoriasin and the antioxidative stress transcription factor nuclear factor erythroid 2\u2010related factor 2 (Nrf2) was investigated. Stimulation with psoriasin not only enhanced <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u03baB translocation and increased the expression of the pro\u2010inflammatory cytokines, interleukin\u20106 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106) and tumor necrosis factor\u2010\u03b1 (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010 \u03b1) but also neurotrophin expression. Evidence for functional interactions between psoriasin and Nrf2 were detected in the form of increased antioxidant response element (<jats:styled-content style=\"fixed-case\">ARE<\/jats:styled-content>) activity and induction of Nrf2\/<jats:styled-content style=\"fixed-case\">ARE<\/jats:styled-content>\u2010dependent heme oxygenase 1 (<jats:styled-content style=\"fixed-case\">HO<\/jats:styled-content>\u20101) expression in psoriasin\u2010treated microglia and astrocytes. The results illustrate the ability of psoriasin to induce immunological functions in glia cells where psoriasin exerts divergent effects on the innate immune response.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc13959-fig-0010-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.13959","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T11:52:56Z","timestamp":1485172376000},"page":"86-99","source":"Crossref","is-referenced-by-count":7,"title":["Psoriasin has divergent effects on the innate immune responses of murine glial 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Ludwig Maximilian University Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Gr\u00f6tzinger","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Michalek","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Pufe","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology RWTH Aachen University Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone 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