{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T14:29:52Z","timestamp":1794061792774,"version":"4.8.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T00:00:00Z","timestamp":1488931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM\/00265"],"award-info":[{"award-number":["CM\/00265"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      We conducted a systematic review and individual participant data meta\u2010analysis to explore the role of C\u2010reactive protein (\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      ) in early detection or prediction of post\u2010stroke infections.\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      , an acute\u2010phase reactant binds to the phosphocholine expressed on the surface of dead or dying cells and some bacteria, thereby activating complement and promoting phagocytosis by macrophages. We searched PubMed up to May\u20102015 for studies measuring\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      in stroke and evaluating post\u2010stroke infections. Individual participants\u2019 data were merged into a single database.\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      levels were standardized and divided into quartiles. Factors independently associated with post\u2010stroke infections were determined by logistic regression analysis and the additional predictive value of\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      was assessed by comparing areas under receiver operating characteristic curves and integrated discrimination improvement index. Data from seven studies including 699 patients were obtained. Standardized\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      levels were higher in patients with post\u2010stroke infections beyond 24\u00a0h. Standardized\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      levels in the fourth quartile were independently associated with infection in two different logistic regression models, model 1 [stroke severity and dysphagia, odds ratio\u00a0=\u00a09.70 (3.10\u201330.41)] and model 2 [age, sex, and stroke severity, odds ratio\u00a0=\u00a03.21 (1.93\u20135.32)]. Addition of\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      improved discrimination in both models [integrated discrimination improvement\u00a0=\u00a09.83% (0.89\u201318.77) and 5.31% (2.83\u20137.79), respectively], but accuracy was only improved for model 1 (area under the curve 0.806\u20130.874,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.036). In this study,\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      was independently associated with development of post\u2010stroke infections, with the optimal time\u2010window for measurement at 24\u201348\u00a0h. However, its additional predictive value is moderate over clinical information. Combination with other biomarkers in a panel seems a promising strategy for future studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc13973-fig-0004-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jnc.13973","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T14:26:40Z","timestamp":1486477600000},"page":"305-314","source":"Crossref","is-referenced-by-count":31,"title":["C\u2010reactive protein in the detection of post\u2010stroke infections: systematic review and individual participant data analysis"],"prefix":"10.1111","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-8900","authenticated-orcid":false,"given":"Alejandro","family":"Bustamante","sequence":"first","affiliation":[{"name":"Neurovascular Research Laboratory Institut de Recerca Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Vilar\u2010Bergua","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory Institut de Recerca Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Guettier","sequence":"additional","affiliation":[{"name":"Department of Neurology Centre Hospitalo\u2010Universitaire C\u00f4te de Nacre Universit\u00e9 Caen\u2010Normandie Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"S\u00e1nchez\u2010Poblet","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory Institut de Recerca Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Garc\u00eda\u2010Berrocoso","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory Institut de Recerca Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona 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