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Since the small <jats:styled-content style=\"fixed-case\">GTP<\/jats:styled-content>ase Rab7A is involved in the trafficking of endosomes, autophagosomes, and lysosomes, and <jats:styled-content style=\"fixed-case\">RAB<\/jats:styled-content>7A gene expression and protein levels are up\u2010regulated in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients, we tested the hypothesis that Rab7A was involved in tau secretion. We previously reported that both primary cortical neurons and HeLa cells over\u2010expressing human <jats:styled-content style=\"fixed-case\">TAU<\/jats:styled-content> can release tau. Using these two cellular systems, we demonstrated that Rab7A regulates tau secretion. Upon Rab7A deletion, tau secretion was decreased. Consistent with this, the over\u2010expression of a dominant negative and a constitutively active form of Rab7A decreased and increased tau secretion, respectively. A partial co\u2010localization of tau and Rab7\u2010positive structures in both neurons and HeLa cells indicated that a late endosomal compartment could be involved in its secretion. Collectively, the present data indicate that Rab7A regulates tau secretion and therefore the up\u2010regulation of <jats:styled-content style=\"fixed-case\">RAB<\/jats:styled-content>7A reported in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, could contribute to the extracellular accumulation of pathological <jats:styled-content style=\"fixed-case\">TAU<\/jats:styled-content> species that could result in the propagation of tau pathology in the <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> brain.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc13994-fig-0007-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.13994","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T18:52:45Z","timestamp":1487703165000},"page":"592-605","source":"Crossref","is-referenced-by-count":66,"title":["Rab7A regulates tau secretion"],"prefix":"10.1111","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5863-3180","authenticated-orcid":false,"given":"Lilia","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Research Center of the University of Montreal Hospital (CRCHUM) Montr\u00e9al Qu\u00e9bec Canada"},{"name":"CNS Research Group (GRSNC) Montreal Qu\u00e9bec Canada"},{"name":"D\u00e9partement de Neurosciences Faculty of Medicine Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec 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