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Here, we investigated whetherCSF<\/jats:styled-content>levels of catecholamines and its metabolites are altered inPD<\/jats:styled-content>patients withLID<\/jats:styled-content>[PD<\/jats:styled-content>\u2010LID<\/jats:styled-content>,n<\/jats:italic>\u00a0=\u00a08)] as compared to non\u2010dyskineticPD<\/jats:styled-content>patients receivingl<\/jats:sc>\u2010DOPA<\/jats:styled-content>(PD<\/jats:styled-content>\u2010L,n<\/jats:italic>\u00a0=\u00a06), or not receivingl<\/jats:sc>\u2010DOPA<\/jats:styled-content>(PD<\/jats:styled-content>\u2010N,n<\/jats:italic>\u00a0=\u00a07) as well as non\u2010PD<\/jats:styled-content>controls (n<\/jats:italic>\u00a0=\u00a016).PD<\/jats:styled-content>patients were clinically assessed using the Unified Parkinson's Disease Rating Scale and Unified Dyskinesia Rating Scale andCSF<\/jats:styled-content>was collected after overnight fasting and 1\u20132\u00a0h after oral intake ofl<\/jats:sc>\u2010DOPA<\/jats:styled-content>or other anti\u2010Parkinson medication.CSF<\/jats:styled-content>catecholamines and its metabolites were analyzed byHPLC<\/jats:styled-content>with electrochemical detection. We observed (i) decreased levels of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid inPD<\/jats:styled-content>patients not receivingl<\/jats:sc>\u2010DOPA<\/jats:styled-content>(ii) higher dopamine (DA<\/jats:styled-content>) levels in PD\u2010LID as compared to controls (iii) higherDA<\/jats:styled-content>\/l<\/jats:sc>\u2010DOPA<\/jats:styled-content>and lowerDOPAC<\/jats:styled-content>\/DA<\/jats:styled-content>ratio's in PD\u2010LID as compared to PD\u2010L and (iv) an age\u2010dependent increase ofDA<\/jats:styled-content>and decrease ofDOPAC<\/jats:styled-content>\/DA<\/jats:styled-content>ratio in controls. These results suggest increasedDA<\/jats:styled-content>release from non\u2010DA<\/jats:styled-content>cells and deficientDA<\/jats:styled-content>re\u2010uptake inPD<\/jats:styled-content>\u2010LID<\/jats:styled-content>. MonitoringDA<\/jats:styled-content>andDOPAC<\/jats:styled-content>inCSF<\/jats:styled-content>ofl<\/jats:sc>\u2010DOPA<\/jats:styled-content>\u2010treatedPD<\/jats:styled-content>patients may help identify patients at risk of developingLID<\/jats:styled-content>.<\/jats:p><\/jats:sec>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.13997","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T07:56:55Z","timestamp":1488268615000},"page":"614-625","source":"Crossref","is-referenced-by-count":40,"title":["Cerebrospinal fluid levels of catecholamines and its metabolites in Parkinson's disease: effect ofl<\/scp>\u2010DOPA<\/scp>treatment and changes in levodopa\u2010induced dyskinesia"],"prefix":"10.1111","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9625-1474","authenticated-orcid":false,"given":"Andreas Dammann","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Neurology Hospital of Southern Jutland S\u00f8nderborg Denmark"},{"name":"Institute of Regional Health Research Center of Southern Jutland University of Southern Denmark Aabenraa Denmark"},{"name":"Focused Research Group in Neurology Hospital of Southern Jutland Aabenraa Denmark"},{"name":"Odense Patient data Exploratory Network Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Blaabjerg","sequence":"additional","affiliation":[{"name":"Department of Neurology Odense University Hospital Odense Denmark"},{"name":"Department of Neurology Zealand University Hospital Roskilde Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Binzer","sequence":"additional","affiliation":[{"name":"Institute of Regional Health Research Center of Southern Jutland University of Southern Denmark Aabenraa Denmark"},{"name":"Focused Research Group in Neurology Hospital of Southern Jutland Aabenraa Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akram","family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Neurology Zealand University Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helle","family":"Thagesen","sequence":"additional","affiliation":[{"name":"Department of Neurology Zealand University Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troels Wesenberg","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Department of Neurology Zealand University Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egon","family":"Stenager","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital of Southern Jutland S\u00f8nderborg Denmark"},{"name":"Institute of Regional Health Research Center of Southern Jutland University of Southern Denmark Aabenraa Denmark"},{"name":"Focused Research Group in Neurology Hospital of Southern Jutland Aabenraa Denmark"},{"name":"The Multiple Sclerosis Clinic of Southern Jutland Vejle, Sonderborg, Esbjerg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Bert Paul","family":"Gramsbergen","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine Neurobiological Research University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540270025015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10714"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.09.009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-3565(25)29316-8","article-title":"The metabolic pathways of L\u20103\u2010O\u2010methyldopa","volume":"183","author":"Bartholini G.","year":"1972","journal-title":"J. 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