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However, the physiological functions of the full length protein and its proteolytic fragments have remained elusive.\n                    <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>\n                    was first described as a cell\u2010surface receptor; nevertheless, increasing evidence highlighted\n                    <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>\n                    as a cell adhesion molecule. In this review, we will focus on the current knowledge of the physiological role of\n                    <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>\n                    as a cell adhesion molecule and its involvement in key events of neuronal development, such as migration, neurite outgrowth, growth cone pathfinding, and synaptogenesis. Finally, since\n                    <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>\n                    is over\u2010expressed in Down syndrome individuals because of the extra copy of chromosome 21, in the last section of the review, we discuss the potential contribution of\n                    <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>\n                    to the neuronal and synaptic defects described in this genetic condition.\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14122-fig-0006-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Read the Editorial Highlight for this article on page<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/doi.org\/10.1111\/jnc.14115\">9<\/jats:ext-link>\n                    .\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Cover Image for this issue: doi.<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1111\/jnc.13817\">10.1111\/jnc.13817<\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/jnc.14122","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T04:46:34Z","timestamp":1499229994000},"page":"11-29","source":"Crossref","is-referenced-by-count":103,"title":["The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous 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