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This study aimed to investigate the key long non\u2010coding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s) correlated with Nrf2, which might provide valuable information for the exploration of pathogenesis of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. The lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression profiling of substantia nigra and corpus striatum of Nrf2 (\u2212\/\u2212) mice model was obtained from microarray analysis. The animal experiments conducted for this study were approved by the ethics committee of Hebei Medical University. Bioinformatics analyses were conducted, including differentially expressed lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s\/<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> (differentially expressed lncRNA, <jats:styled-content style=\"fixed-case\">DEL<\/jats:styled-content>\/differentially expressed mRNA, <jats:styled-content style=\"fixed-case\">DEM<\/jats:styled-content>) identification, <jats:styled-content style=\"fixed-case\">DEL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DEM<\/jats:styled-content> coexpression network construction, and biological functions prediction. Quantitative real\u2010time polymerase chain reaction (<jats:styled-content style=\"fixed-case\">qRT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>) was subjected to validate abnormally expressed <jats:styled-content style=\"fixed-case\">DEL<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">DEM<\/jats:styled-content>s in the substantia nigra and corpus striatum of Nrf2 (\u2212\/\u2212) mice model. A total of 48 <jats:styled-content style=\"fixed-case\">DEL<\/jats:styled-content>s (37 down\u2010regulated and 11 up\u2010regulated) were identified both in Nrf2 (\u2212\/\u2212) substantia nigra and corpus striatum; 96 <jats:styled-content style=\"fixed-case\">DEM<\/jats:styled-content>s and 643 <jats:styled-content style=\"fixed-case\">DEM<\/jats:styled-content>s were identified in the substantia nigra and corpus striatum, respectively. <jats:styled-content style=\"fixed-case\">DEL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DEM<\/jats:styled-content> coexpressed network was constructed. Lnc<jats:styled-content style=\"fixed-case\">RNA AK<\/jats:styled-content>076880, <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>036620, and <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>020330 had high connectivity with <jats:styled-content style=\"fixed-case\">DEM<\/jats:styled-content>s both in the substantia nigra and corpus striatum. These <jats:styled-content style=\"fixed-case\">DEM<\/jats:styled-content>s were significantly enriched in signaling pathways such as the calcium signaling pathway, Huntington's disease, Alzheimer's disease, mitogen\u2010activated protein kinase (<jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>) signaling pathway, and the Wnt signaling pathway. Generally, <jats:styled-content style=\"fixed-case\">qRT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> validation results of selected <jats:styled-content style=\"fixed-case\">DEM<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">DEL<\/jats:styled-content>s were consistent with microarray data. The dysregulated <jats:styled-content style=\"fixed-case\">DEL<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">DEM<\/jats:styled-content>s in the substantia nigra and corpus striatum of Nrf2\u00a0(\u2212\/\u2212) mice were identified. Our results might provide useful information for further exploring the pathogenesis mechanism of PD.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14141-fig-0005-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.14141","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T20:29:08Z","timestamp":1501792148000},"page":"65-75","source":"Crossref","is-referenced-by-count":10,"title":["The aberrantly expressed long non\u2010coding <scp>RNA<\/scp> in\u00a0the substantia nigra and corpus striatum of Nrf2\u2010knockout mice"],"prefix":"10.1111","volume":"143","author":[{"given":"Jian","family":"Liu","sequence":"first","affiliation":[{"name":"Department 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