{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:53:20Z","timestamp":1790787200749,"version":"4.1.0"},"reference-count":137,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Subcortical ischemic vascular cognitive impairment (SIVCI) is the most preventable form of cognitive dysfunction. There is converging evidence from animal and human studies that indicate vascular injury as the primary cause of SIVCI. Currently, there are no curative pharmaceutical treatments for vascular dementia; however, exercise may be a promising strategy to combat SIVCI. This review will focus on the role of exercise as a strategy to prevent or slow the progression of SIVCI, with particular emphasis on the mechanisms by which exercise may improve cerebrovascular function. We propose that exercise may be an effective strategy to combat SIVCI by improving cognitive function, increasing the bioavailability of neurotrophins, stimulating endothelial function, and controlling vascular risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14153-fig-0002-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/journal\/10.1111\/(ISSN)1471-4159\/homepage\/special_issues.htm#Vascular Dementia\">This article is part of the Special Issue \u201cVascular Dementia\u201d<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.14153","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T08:52:42Z","timestamp":1503305562000},"page":"582-594","source":"Crossref","is-referenced-by-count":26,"title":["The role of exercise in mitigating subcortical ischemic vascular cognitive impairment"],"prefix":"10.1111","volume":"144","author":[{"given":"Elizabeth","family":"Dao","sequence":"first","affiliation":[{"name":"Department of Physical Therapy University of British Columbia (UBC) Vancouver Canada"},{"name":"Djavad Mowafaghian Centre for Brain Health UBC Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ging\u2010Yuek Robin","family":"Hsiung","sequence":"additional","affiliation":[{"name":"Djavad Mowafaghian Centre for Brain Health UBC Vancouver Canada"},{"name":"Department of Medicine Division of Neurology UBC Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1016-196X","authenticated-orcid":false,"given":"Teresa","family":"Liu\u2010Ambrose","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of British Columbia (UBC) Vancouver Canada"},{"name":"Djavad Mowafaghian Centre for Brain Health UBC Vancouver Canada"},{"name":"Centre for Hip Health and Mobility Vancouver Coastal Health Research Institute Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.12.1447"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00437.2012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12306"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.2.246"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.307"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.871"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.05.016"},{"key":"e_1_2_8_9_1","first-page":"657508","article-title":"A review of the effects of physical activity and exercise on cognitive and brain functions in older adults","volume":"2013","author":"Bherer L.","year":"2013","journal-title":"J. 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