{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:09:53Z","timestamp":1790467793374,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Calgary Katthy Taylor Chair in Vascular Dementia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Sporadic, age\u2010related cerebral amyloid angiopathy (<jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>) is most commonly recognized clinically as a cause of hemorrhagic stroke and transient focal neurological episodes in older persons. But a growing body of research in the last 5\u00a0years shows that the pathophysiology of <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content> is much more complex than previously believed, leading to many different types of brain injury. <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content> has now been linked with brain atrophy in regions remote from those directly affected by intracerebral hematomas, and with risk for progressive cognitive decline in the absence of new hemorrhagic strokes. Therefore, <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content> is associated with features \u2013 brain atrophy and progressive cognitive decline \u2013 that are typically considered hallmarks of neurodegenerative disease. Although <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content> is usually accompanied by some degree of Alzheimer's disease pathology, the profiles of cortical thinning and cognitive impairment do not fully overlap with those seen in Alzheimer's disease, suggesting that there are <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>\u2010specific pathways of neurodegeneration. <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>\u2010related brain ischemia may be an important mechanism that leads to brain injury, cortical disconnection, and cognitive impairment.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14157-fig-0005-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/journal\/10.1111\/(ISSN)1471-4159\/homepage\/special_issues.htm#Vascular Dementia\">This article is part of the Special Issue \u201cVascular Dementia\u201d<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.14157","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T11:56:42Z","timestamp":1503316602000},"page":"651-658","source":"Crossref","is-referenced-by-count":82,"title":["Cerebral amyloid angiopathy as a cause of neurodegeneration"],"prefix":"10.1111","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3956-1668","authenticated-orcid":false,"given":"Eric E.","family":"Smith","sequence":"first","affiliation":[{"name":"Associate Professor of Neurology University of Calgary Health 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