{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T06:05:47Z","timestamp":1775109947213,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T00:00:00Z","timestamp":1510790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81120108011 and 81200893"],"award-info":[{"award-number":["81120108011 and 81200893"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Depression has been associated with a low\u2010grade chronic inflammatory state, suggesting a potential therapeutic role for anti\u2010inflammatory agents. Fisetin is a naturally occurring flavonoid in strawberries that has anti\u2010inflammatory activities, but whether fisetin has antidepressant effects is unknown. In this study, we exposed mice to spatial restraint for 2\u00a0weeks with or without treatment with fisetin. Immobility time in the forced swimming and tail suspension test after this restraint increased in the untreated group, but this increase did not occur in the fisetin group. We administered fisetin to Abelson helper integration site\u20101 (Ahi1) knockout mice, which have depressive phenotypes. We found that fisetin attenuated the depressive phenotype of these Ahi1 knockout mice. We further investigated the potential mechanism of fisetin's antidepressant effects. Because TrkB is a critical signaling pathway in the mechanisms of depression, we examined whether phosphorylated TrkB was involved in the antidepressant effects of fisetin. We found that fisetin increased phosphorylated TrkB level without altering total TrkB; this increase was attenuated by K252a, a specific TrkB inhibitor. Taken together, our results demonstrated that fisetin may have therapeutic potential for treating depression and that this antidepressant effect may be mediated by the activation of the TrkB signaling pathway.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14226-fig-0007-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.14226","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T16:03:15Z","timestamp":1506355395000},"page":"561-568","source":"Crossref","is-referenced-by-count":46,"title":["Fisetin provides antidepressant effects by activating the tropomyosin receptor kinase B signal pathway in mice"],"prefix":"10.1111","volume":"143","author":[{"given":"Yamin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology the Second Affiliated Hospital of Soochow University Suzhou City China"},{"name":"Institute of Neuroscience Soochow University Suzhou City Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Soochow University Suzhou City Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Soochow University Suzhou City Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixia","family":"Shi","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Soochow University Suzhou City Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyi","family":"Gong","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Soochow University Suzhou City Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Soochow University Suzhou City Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald C.","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Cecile Cox Quillen Laboratory of Geriatrics College of Medicine East Tennessee State University Johnson City Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balvin H. 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