{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:23:55Z","timestamp":1762352635977,"version":"3.37.3"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["16K08557","15K08245","15H04689"],"award-info":[{"award-number":["16K08557","15K08245","15H04689"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurochemistry"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Humanin and calmodulin\u2010like skin protein (CLSP) inhibits Alzheimer disease (AD)\u2010related neuronal cell death via the heterotrimeric humanin receptor <jats:italic>in\u00a0vitro<\/jats:italic>. It has been suggested that CLSP is a central agonist of the heterotrimeric humanin receptor <jats:italic>in\u00a0vivo<\/jats:italic>. To investigate the role of CLSP in the AD pathogenesis <jats:italic>in\u00a0vivo<\/jats:italic>, we generated mouse <jats:italic>CLSP\u20101<\/jats:italic> transgenic mice, crossed them with the <jats:italic>APPswe\/PSEN1dE9<\/jats:italic> mice, a model mouse of AD, and examined the effect of CLSP over\u2010expression on the pathological phenotype of the AD mouse model. We found that over\u2010expression of the mouse <jats:italic>CLSP\u20101<\/jats:italic> gene attenuated spatial learning impairment, the loss of a presynaptic marker synaptophysin, and the inactivation of STAT3 in the <jats:italic>APPswe\/PSEN1dE9<\/jats:italic> mice. On the other hand, CLSP over\u2010expression did not affect levels of A\u03b2, soluble A\u03b2 oligomers, or gliosis. These results suggest that the CLSP\u2010mediated attenuation of memory impairment and synaptic loss occurs in an A\u03b2\u2010independent manner. The results of this study may serve as a hint to the better understanding of the AD pathogenesis and the development of AD therapy.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jnc14258-fig-0009-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnc.14258","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T03:42:44Z","timestamp":1511322164000},"page":"218-233","source":"Crossref","is-referenced-by-count":14,"title":["Calmodulin\u2010like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease"],"prefix":"10.1111","volume":"144","author":[{"given":"Shinya","family":"Kusakari","sequence":"first","affiliation":[{"name":"Department of Pharmacology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikiro","family":"Nawa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuko","family":"Sudo","sequence":"additional","affiliation":[{"name":"Pre\u2010clinical Research Center Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-3346","authenticated-orcid":false,"given":"Masaaki","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Tokyo Medical University Tokyo Japan"},{"name":"Department of Dermatological Neuroscience Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.02.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1000-15.2015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13062"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30459"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.105"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270502"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1662-x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205013666160129095924"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.08.017"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.09.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2101"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.03.031"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e09-02-0168"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.80"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01616412.2017.1335458","article-title":"Calmodulin\u2010like skin protein is downregulated in human cerebrospinal fluids of Alzheimer's disease patients with apolipoprotein E4; a pilot study using postmortem samples","volume":"39","author":"Hashimoto Y.","year":"2017","journal-title":"Neurol. 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